3-氧杂-8-氮杂双环[3.2.1]辛烷盐酸盐的合成  

Synthesis of 3-Oxa-8-azabicyclo[3.2.1]octane Hydrochloride

作　　者：王荣宽 卓广澜[1] 

机构地区：[1]浙江理工大学理学院,浙江杭州310018

出　　处：《合成化学》2016年第11期998-1001,共4页Chinese Journal of Synthetic Chemistry

摘　　要：以己二酸为初始原料,依次经酰氯化,溴代,苄胺环合,水解,还原,脱水环合,氢解脱苄和成盐等8步反应,合成了3-氧杂-8-氮杂双环[3.2.1]辛烷盐酸盐,总收率23%,纯度100%,其结构经1H NMR确证。3-Oxa-8-azabicyclo[3.2. 1 ] octane hydrochloride with overall yield of 23% and purity of 100% was synthesized by a eight-step reaction of chlorination, bromination, benzylamine cyclization, hydrolysis, reduction, dehydration condensation, debenzylation hydrogenolysis and salt-forming. The structure was confirmed by 1H NMR.

关 键 词：己二酸 3-氧杂-8-氮杂双环[3.2.1]辛烷盐酸盐 药物合成 

分 类 号：O624.6[理学—有机化学] R914.5[理学—化学]