贝那普利联合氨氯地平治疗原发性高血压的临床研究  

Clinical study of benazapril combined with amlodipine in treatment of essential hypertension

作　　者：李雪玲[1] 邢光[1] 李群[1] 

机构地区：[1]北京丰台医院心内科,北京100071

出　　处：《中国医药科学》2016年第16期57-59,137,共4页China Medicine And Pharmacy

摘　　要：目的 对贝那普利联合氨氯地平治疗原发性高血压进行研究。方法 选择2013年8月~2015年8月入住我院的资料完整的原发性高血压患者160例患者作为研究对象,将其治疗方法不同随机分为观察组和对照组,每组各80例。两组均采取非药物治疗措施,对照组口服贝那普利,观察组联合氨氯地平治疗,治疗2个月后评价两组的临床疗效及两组患者治疗前后SBP、DBP的变化情况,并对比分析两组治疗4周后、治疗8周后的24 h ABPVs、24 h ABPVd的变化情况。结果 观察组总有效率为95%,对照组总有效率为75%,两组临床总有效率比较,差异有统计学意义（P〈0.05）,治疗2个月后,两组的SBP、DBP水平均分别较治疗前显著降低,其中,观察组治疗后SBP（120.28±20.22）mm Hg,DBP（83.20±11.23）mm Hg,分别与对照组比较,观察组治疗后的SBP、DBP水平显著低于对照组,差异具有显著性（P〈0.05）,观察组治疗8周后的24h ABPVs、24h ABPVd分别显著低于对照组,差异具有显著性（P〈0.05）。结论 贝那普利联合氨氯地平治疗原发性高血压临床疗效显著提高,降压效果显著,有效降低高血压患者的血压变异性,有效协助降压,维持血压稳定,值得推广和应用。Objective To study the effect of benazapril combined with amlodipine in treatment of essential hypertension. Methods 160 cases of patients with essential hypertension with complete data cured in our hospital from August 2013 to August 2015 were selected as the research object. They were randomly divided into observation group and control group with 80 cases in each. All the patients in the two groups were treated with the non-drug treatment, patients in control group were treated with benazapril, and patients in observation group were treated with benazapril combined with amlodipine. After treatment 2 months, the therapeutic effect and SBP, DBP changes before and after treatment between the two groups were compared. The changes of 24h ABPVs and 24h ABPVd after 4 weeks and 8 weeks treatment were compared and analyzed. Results The total effective rate of observation group was 95%, and the total effective of control group was 75%, and the difference was statistically significant （P 〈 0.05）. After 2 months of treatment, SBP and DBP levels of the two groups were significantly lower than those before treatment, the SBP and DBP of observation group after treatment was （120.28 ＋ 20.22） mm Hg, （83.20 ＋ 11.23）ram Hg, respectively. The SBP and DBP of observation group after treatment were significantly lower than those of control group after treatment （P 〈 0.05）. The 24 ABPVs, 24 h ABPVd of observation group after 8 weeks of treatment were significantly lower than those of control group, and the difference was significant （P 〈 0.05）. Conclusion The clinical curative effect of benazapril and amlodipine in the treatment of primary hypertension is significantly improved, and the antihypertensive effect is significant. It can effectively reduce the blood pressure variability of patients with essential hypertension, and effectively assist in reducing blood pressure and maintaining stable blood pressure. It is worthy of promotion and application.

关 键 词：原发性高血压 贝那普利 联合 氨氯地平 血压变异性 

分 类 号：R544.1[医药卫生—心血管疾病]