西替利嗪辅助治疗对哮喘患儿炎性因子及临床症状的影响  

The Influence of Inflammatory Factor and Clinical Symptoms of Cetirizine Adjuvant Therapy for Asthma in Children

作　　者：李菲 江桂松 

机构地区：[1]丹东市第一医院,辽宁丹东118000

出　　处：《儿科药学杂志》2016年第11期10-13,共4页Journal of Pediatric Pharmacy

基　　金：丹东市科学技术计划项目;编号15403-2

摘　　要：目的:探讨西替利嗪辅助治疗对哮喘患儿炎性因子及临床症状的影响。方法:将我院儿科2015年2-5月收治的80例哮喘患儿随机分为观察组和对照组各40例,对照组在常规治疗的基础上采用布地奈德雾化吸入,观察组在对照组治疗的基础上加用西替利嗪,两组均以5 d为1个疗程,治疗1个疗程后进行相关指标的比较。结果:两组患儿治疗后的炎性因子(TNF-α、IL-6、IL-10)水平、临床症状评分、肺功能(FVC、FEV1、PEFR)均较治疗前改善(P均<0.05),且观察组的改善幅度均大于对照组(P均<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:西替利嗪辅助治疗能够显著降低哮喘患儿的炎性因子水平,改善临床症状和肺功能,且不会增加不良反应。Objective： To explore the influence of inflammatory factor and clinical symptoms of cetirizine adjuvant therapy for asthma in children. Methods： Eighty cases of children with asthma in our hospital from February to May 2015 were divided into two groups by random number method. Control group（ 40 cases） on the basis of routine treatment with budesonide aerosol inhalation,on the basis of the control group,the observation group was treated with cetirizine,both set to 5 d for a period of treatment. Relevant indicators on the end of one course were compared. Results： The two groups after treatment of clinical symptoms,pulmonary function and inflammatory factor were improved significantly,the differences were statistically significant（ P〈0.05）. But the above indicators to improve the level of the observation group were better than control group,the differences were statistically significant（ P〈0.05）. The adverse reactions in two groups had no statistical significance（ P〉0. 05）. Conclusion： Atomizing inhaled corticosteroids and H1 receptor blockers can significantly improve the clinical symptoms and lung function in children with asthma,reduce the levels of inflammatory factors and adverse reaction.

关 键 词：西替利嗪 辅助治疗 H1受体阻滞剂 炎性因子 

分 类 号：R725.6[医药卫生—儿科]