Ⅱ型糖尿病患者胰岛素强化治疗对颈动脉内膜中层厚度及血清胱抑素C水平的影响  

Predicting effects of glycemic control on common carotid artery intima-medial thickness progression and plasma Cys-c level in type 2 diabetes mellitus,intensive insulin

作　　者：刘宜东[1] 钟晓卫[1] 李华琦[1] 傅徐泉[1] 严同[1] 陈利鸿[1] 杨梅[1] 

机构地区：[1]成都市第三人民医院内分泌科,四川成都610031

出　　处：《西部医学》2016年第11期1510-1513,共4页Medical Journal of West China

基　　金：四川省卫生厅科研课题(100024)

摘　　要：目的探讨Ⅱ型糖尿病患者胰岛素强化治疗控制血糖对于颈动脉内膜中层厚度(CCA-IMT)、血清胱抑素C(Cys-c)的影响程度。方法选择88例Ⅱ型糖尿病患者,随机均分为强化组和对照组,每组44例,强化组给予胰岛素强化治疗,对照组给予口服降糖药物治疗;在治疗3、6个月后比较两组患者的CCA-IMT、Cys-c、HbA1c等相关指标的变化情况。结果所有患者经过治疗后,CCA-IMT、Cys-c、糖化血红蛋白(HbA1c)等指标都较治疗前有所下降,且Cys-c、HbA1c强化组较对照组下降更明显,差异具有统计学意义(P<0.05)。结论降糖治疗对大血管病变有益处,但胰岛素强化治疗较口服降糖药对其大血管并发症进展的控制无优势。Objective To observation of type 2 diabetic patients with insulin common carotid artery intima-medial thickness progression and plasma Cys-c level and explore diabetes patients with blood glucose control for the effect CCA- IMT and Cys-c. Methods 96 patients with Type 2 Diabetic patients were randomly divided into strengthen group （48 cases） and observe group （48 cases）. The strengthen group was treated with insulin intensive therapy. The observe group was treated with oral drugs. Three and six months after treatment CCA-IMT, Cys-c and HbAlc were observed. Results CCA-IMT, Cys-c and HbAlc after treatment decreased. Cys-c and HbAlc in strengthen group more obviously decreased than that in observe group. The difference was statistically significant （P〈0.05）. Conclusion Intensive insulin and oral drugs therapy are beneficial to the macrovascular complications, but intensive insulin therapy has no advantage the progression of macrovascular complications in type 2 diabetes.

关 键 词：Ⅱ型糖尿病 胰岛素强化治疗 颈动脉内膜中层厚度 血清胱抑素C 

分 类 号：R587.1[医药卫生—内分泌]