6种儿茶酚衍生物对小鼠焦虑样行为的影响  

Anxiolytic/anxiogenic effects of six catechol derivatives in mice

作　　者：王小红[1] 张婵溪 翟海峰[2] 黄建梅[1] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]北京大学中国药物依赖性研究所,北京100191

出　　处：《中华中医药杂志》2016年第11期4787-4789,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金资助项目(No.81173541)~~

摘　　要：目的:明确儿茶酚衍生物苯环上羟基及甲氧基取代对小鼠焦虑行为的影响。方法:采用小鼠高架十字迷宫模型,评价含有酚羟基的3,4-二羟基苯乙酮、香草乙酮、阿魏酸和不含酚羟基的3,4-二甲氧基肉桂酸、甲基丁香酚、甲基香草醛等儿茶酚衍生物对小鼠焦虑行为的影响。结果:含有2个酚羟基的3,4-二羟基苯乙酮(20mg/kg)具有明显的抗焦虑活性(P<0.01);含有1个酚羟基的阿魏酸(5、10、20mg/kg)具有明显的抗焦虑作用(P<0.05,P<0.01),而香草乙酮有增加评价指标的趋势但无显著抗焦虑作用;不含酚羟基的3,4-二甲氧基肉桂酸无抗焦虑和致焦虑活性,甲基丁香酚(5mg/kg)及甲基香草醛(1.25mg/kg)具有明显的致焦虑活性(P<0.05,P<0.01)。结论:儿茶酚苯环上羟基、甲氧基取代衍生物可分别产生抗焦虑、致焦虑两种相反的作用,儿茶酚衍生物影响小鼠焦虑行为的构效关系值得深入研究。Objective： To clarity the effects of catechol derivatives with hydroxyl or methoxy groups in substituted on anxiety behaviors in mice. Methods： The effects of catechol derivatives contained 3,4-dihydroxyacetophenone, acetovanillone, ferulic acid and did not contain 3,4-dihydroxyacetophenone, methyleugenol, methylvanillin on the anxiety behavior of mice were evaluated by elevated plus maze. Results： In the elevated plus maze, 3,4-dihydroxyacetophenone（20mg/kg） with two phenolic hydroxyl showed significant anxiolytic effects（P〈0.01）. Ferulic acid（5, 10, 20 mg/kg） with one phenolic hydroxyl had significant anxiolytic effects（P〈0.05, P〈0.01）, while acetovanillone showed an increasing trend in the evaluation index but without significant anxiolytic effect. 3,4-dimethoxycinnamic acid without phenolic hydroxyl did not have anxiolytic or anxiogenic activity. However, methyleugenol（5mg/kg）, methylvanillin（1.25mg/kg） showed obviously anxiogenic activities（P〈0.05, P〈0.01）. Conclusion： Catechol derivatives with hydroxyl or methoxy groups in substituted had anxiolytic or anxiogenic effects on the anxiety behaviors in mice, the specific structure-activity relationship was worthy of further investigation.

关 键 词：儿茶酚衍生物 酚羟基 抗焦虑 致焦虑 

分 类 号：R285.5[医药卫生—中药学]