妊娠期糖尿病胎盘病理与串珠素关系研究  

Research on the Relationship Between Placenta Pathology in Gestational Diabetes Mellitus and Perlecan

作　　者：赵亚娟[1] 冷冬月 余汉风 陈双郧[1] 

机构地区：[1]湖北医药学院附属十堰市太和医院,湖北十堰442000 [2]钟祥市人民医院,湖北钟祥431900

出　　处：《河南中医》2016年第10期1821-1822,共2页Henan Traditional Chinese Medicine

基　　金：湖北省十堰市科技攻关项目(编号:2010st19)

摘　　要：目的:探讨妊娠期糖尿病胎盘的病理改变及其与串珠素表达的关系。方法:取妊娠期糖尿病及正常妊娠足月分娩胎盘各30例,石蜡切片,光镜下观察两组胎盘形态,免疫组织化学法标记胎盘组织中串珠素的表达水平。结果:病例组胎盘存在明显的干绒毛小动脉增生、绒毛成熟不良及毛细血管充盈现象,串珠素表达水平明显高于对照组,差异具有统计学意义(P<0.05)。结论:妊娠期糖尿病导致胎盘血管病理改变与串珠素的表达水平增高有关。Objective：To explore the relationship between pathological changes of the placenta in patients with gestational diabetes mellitus（GDM） and the expression of Perlecan, Methods：Select 30 placentas of patients with GDM and 30 placentas of women with normal gestation and term delivery,perform paraffin section,observe the shapes of the placentas in both groups,mark the expression level of the Perlecan in placentas by immunohistochemieal method. Results：There were obvious dry villi arteriole hyperplasia,unhealthy mature of the villi and replenishing phonomenon of the blood capillary in the medical cases group, and the expression level of the Perleean was higher than that in control group;the difference had statistical signficance （P 〈 0.05 ）, Conclusion：There is relationship between the pathological change of the placentas caused by GDM and expression level of Perlecan.

关 键 词：妊娠期糖尿病 胎盘 串珠素 

分 类 号：R271.914.56[医药卫生—中西医结合]