2-辛亚砜-5,8-二甲氧基-1,4萘醌通过ROS/Akt通路诱导HepG2细胞凋亡  

2-(octane-1-sulfinyl)-5,8-Dimethoxy-1,4-Naphthoquinone Induce HepG2 Apoptosis through ROS/Akt and MAPKs Pathway

作　　者：邱美玉 刘军[1] 申贵男 崔玉东[1] 韩英浩[1] 

机构地区：[1]黑龙江八一农垦大学生命科学技术学院,大庆163319

出　　处：《黑龙江八一农垦大学学报》2016年第5期81-86,共6页journal of heilongjiang bayi agricultural university

基　　金：黑龙江八一农垦大学校科研启动计划项目(XYB2012-12)

摘　　要：为研究修饰后的萘醌类衍生物对人肝癌细胞株HepG2诱导细胞凋亡作用及其机制。采用MTT、流式和Western blot方法观察2-辛亚砜-5,8-二甲氧基-1,4萘醌对人肝癌细胞的生长作用。结果表明:2-辛亚砜-5,8-二甲氧基-1,4萘醌可通过促进早期ROS水平升高,抑制Akt的磷酸化水平,并选择性地激活p38,ERK信号通路,从而抑制肝癌细胞株HepG2细胞的增殖并诱导其发生凋亡。To investigate the effects of modified naphthoquinone derivatives on apoptosis in hepatocellular carcinoma HepG2 cells and its underlying mechanism. The effect of 2-（octane-1-sulfinyl）-5,8-Dimethoxy-1,4-Naphthoquinone on the growth of human hepatocellular carcinoma cells was observed by MTT,flow and Western blot method.The results showed that 2-（octane-1-sulfinyl）-5,8-Dimethoxy-1,4-Naphthoquinone could elevate ROS level,inhibit phosphorylation of Akt,selectively activate p38 and ERK signaling pathway,thus inhibite proliferation and induce apoptosis of HepG2 cell.

关 键 词：萘醌类衍生物 HEPG2 增殖抑制 活性氧 

分 类 号：R285[医药卫生—中药学]