脱氢表雄酮在辅助生殖技术中的研究进展  

Research on dehydroepiandrosterone in assisted reproductive technology

作　　者：胡乔飞[1] 杨晓葵[2] 

机构地区：[1]首都医科大学附属北京妇产医院计划生育科,北京100026 [2]首都医科大学附属北京妇产医院生殖医学科,北京100026

出　　处：《中国优生与遗传杂志》2016年第9期1-3,共3页Chinese Journal of Birth Health & Heredity

基　　金：国家自然科学基金项目(81170542);北京市自然科学基金项目(7152055)

摘　　要：卵巢储备功能下降(diminished ovarian reserve,DOR)是指患者卵泡数量减少和/或卵母细胞质量下降。DOR是导致女性不孕及体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)过程中卵巢低反应甚至周期取消的重要原因之一。近年来,有关脱氢表雄酮(DHEA)改善卵巢储备和卵巢反应性方面的研究逐渐增多,但其有效性仍存在争议。本文就DHEA在DOR女性中的临床应用效果及可能的作用机制进行综述。Diminished ovarian reserve（DOR）is characterized by reduced number of follicles and/or declined quality of oocytes. Women with DOR not only suffer from less fertility,but they can also likely to experience poor ovarian response and cycle cancellation in the process of in vitro fertilization-embryo transfer（IVF-ET）. Recently,accumulating evidences have shown that dehydroepiandrosterone（DHEA） may play a role in improving the ovarian reserve and response of women with DOR. However,the effectiveness of DHEA remains controversial. This review summarized the clinical effects and possible mechanisms of DHEA in the treatment of women with DOR.

关 键 词：脱氢表雄酮 卵巢储备功能 辅助生殖技术 

分 类 号：R714.8[医药卫生—妇产科学]