前额叶^1H-MRS波谱成像与2型糖尿病患者的关系  

Relationship between ^1H-MRS measurement of prefrontal cortex and patients with type 2 diabetes mellitus

作　　者：王存强[1] 贺顺岭 顾韵泽 原子扬 王文娜[1] 刘晓琨[1] 

机构地区：[1]河南省新乡市第一人民医院磁共振科,453000

出　　处：《中国实用医刊》2016年第19期81-83,共3页Chinese Journal of Practical Medicine

摘　　要：目的 研究2型糖尿病患者前额叶氢质子磁共振波谱（^1H-MRS）的特点.方法 随机选取2013年2月至2015年1月32例2型糖尿病患者为研究组,另选取同期健康志愿者30例为对照组.采用1 H-MRS检测前额叶的N-乙酰基天门冬氨酸（NAA）、胆碱复合物（Cho）和肌酸复合物（Cr）.结果 研究组双侧前额叶NAA/Cr值低于对照组,差异有统计学意义（P〈0.05）;研究组双侧前额叶Cho/Cr值高于对照组,差异有统计学意义（P〈0.05）.结论 2型糖尿病患者存在前额叶神经元的代谢异常.Objective To identify the metabolite levels on prefrontal cortex in patients with type 2 diabetes mellitus by ^1H-MRS.Methods Thirty-two patients with type 2 diabetes mellitus were randomly selected as research group from February 2013 to January 2015,and 30 healthy volunteers were selected as control group.1 H-MRS was given to all the subjects on prefrontal cortex.The ratios of NAA/Cr and Cho/Cr were determined.Results In the bilateral prefrontal cortex,the NAA/Cr ratio of research group was lower than that of control group,the difference was significant （P 〈 0.05）,the Cho/Cr ratio of research group was higher than that of control group,the difference was significant （P 〈 0.05）.Conclusions Abnormal metabolism of neurons on prefrontal cortex in patients with type 2 diabetes mellitus.

关 键 词：2型糖尿病 氢质子磁共振波谱分析 前额叶 

分 类 号：R587.1[医药卫生—内分泌]