安徽省耐多药肺结核危险因素病例对照研究  

Risk factors of multidrug-resistant tuberculosis in Anhui Province: A case-control study

作　　者：余述凤 梅晓冬[1] 阚晓宏 方雪晖 包训迪 

机构地区：[1]安徽医科大学附属安徽省立医院呼吸内科,安徽合肥230001 [2]安徽省胸科医院呼吸内科,安徽合肥230022 [3]安徽省胸科医院科教科,安徽合肥230022 [4]安徽省胸科医院检验科,安徽合肥230022

出　　处：《中华疾病控制杂志》2016年第10期1026-1028,共3页Chinese Journal of Disease Control & Prevention

基　　金：安徽省卫计委科研基金(2011Y0107)

摘　　要：目的探讨安徽省耐多药肺结核的危险因素。方法采用病例对照研究方法,病例组为83名耐多药肺结核病人,对照组为98名已治愈的非耐药肺结核病人,以问卷调查形式收集资料。结果居住地为农村、文化程度为初中及以下、家庭人均月收入少、外出务工、吸烟、服用抗结核药物产生不良反应、既往抗肺结核治疗次数多、既往有某个疗程中暂时停药或暂时中断治疗、首次确诊时X线检查肺内病灶多、空洞多、首次抗结核治疗效果未治愈都是耐多药肺结核的危险因素(均有P<0.05);病人接受过结核病知识以及治疗过程中有关服药原则的宣传和教育、>7 h的睡眠时间是耐多药肺结核的保护因素(均有P<0.05)。结论导致安徽省耐多药肺结核发生的危险因素较多,适当的宣传教育和充足的睡眠有助于减少耐多药肺结核的发生。Objective To investigate the risk factors of muhidrug-resistant tuberculosis in Anhui Province. Methods 83 patients with multidrug-resistant pulmonary tuberculosis and 98 cured patients with non drug-resistant pulmonary tuberculosis were collected and analyzed with case-control study. Results Rural residence, junior high school education level and below, less family month income, migrant work, smoking, experience of adverse reactions of anti-tuberculosis drugs, history of repeated tuberculosis treatment, history of discontinuation or temporary interruption of anti-tuberculosis therapy, lung X ray image with multiple lesions or cavities when tuberculosis was diagnosed, and once first treatment failure were risk factors of muhidrug-resistant tuberculosis （ all P 〈 0. 05 ） ; equipped with tuberculosis knowledge or related medi- cation taking principle popularization and sleeping time 〉 7 hours were protective factors （ all P 〈 0. 05 ）. Conclusions The risk factors of multidrug-resistance tuberculosis in Anhui Province are various. Adequate tuberculosis education and sufficient sleep might be beneficial to the disease.

关 键 词：广泛耐药结核 危险因素 病例对照研究 

分 类 号：R521[医药卫生—内科学] R181.2[医药卫生—临床医学]