肺炎链球菌脑膜炎发病机制及辅助治疗的研究进展  

Pathogenesis and adjuvant therapy for pneumococcal meningitis

作　　者：徐桂霞[1] 刘心洁[2] 

机构地区：[1]泰山医学院附属聊城市第二人民医院儿科加强病房,临清252601 [2]山东大学齐鲁医院儿童医疗中心,济南250012

出　　处：《中国小儿急救医学》2016年第9期626-630,共5页Chinese Pediatric Emergency Medicine

摘　　要：肺炎链球菌脑膜炎是小儿时期最常见的中枢神经系统感染性疾病之一，临床上以急性发热、惊厥、意识障碍、颅内压增高和脑膜刺激征及脑脊液脓性改变为特征。随着抗生素的应用及肺炎链球菌疫苗的接种，本病的发病率和病死率明显下降。但是耐药菌的不断出现和新的临床抗菌药物研发的相对滞后，其仍具有较高的病死率及致残率，这些均促进了针对肺炎链球菌脑膜炎发病机制及辅助治疗研究的不断深入。本文对近年来肺炎链球菌脑膜炎的发病机制及辅助治疗的研究进展作一综述。Pneumococcal meningitis is one of the most common infectious diseases of the central nervous system in pediatric period which is characterized by acute fever,unconvulsions,consciousness,in-creased intracranial pressure and meningeal irritation and cerebrospinal fluid pus changes in clinic. With the advent of antibiotics and pneumococcal vaccination,the morbidity and mortality of the disease decline signifi-cantly. But due to the appearance of drug-resistant bacteria and the relative lag of research and development speed of clinical new antibacterial drugs,it still has high mortality and morbidity which are promoting resear-ches of pathogenesis and adjuvant therapy. In this paper,researches of pathogenesis and adjuvant therapy for preumococcal meningitis were reviewed in recent years.

关 键 词：肺炎链球菌 脑膜炎 辅助治疗 

分 类 号：R725.1[医药卫生—儿科]