肠道微生态与肝癌关系研究新进展  

The Cutting Edge of Research Advance on the relationship between intestinal microecology and hepatocellular carcinoma

作　　者：蒋建文[1,2,3] 任志刚[1,4] 郑树森[1,2] JIANG Jian-wen REN Zhi-gang ZHENG Shu-sen(Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang Universit Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang 310003, Chin)

机构地区：[1]浙江大学医学院附属第一医院肝胆胰外科,卫生部多器官联合移植重点实验室,杭州310003 [2]浙江大学医学院附属第一医院感染性疾病诊治协同创新中心,杭州310003 [3]浙江大学医学院附属第一医院国际保健中心,杭州310003 [4]郑州大学第一附属医院感染科,450002

出　　处：《传染病信息》2016年第5期264-266,283,共4页Infectious Disease Information

基　　金：浙江省医药卫生科学研究基金(2014KYB081);浙江省自然科学基金(LY15H160033);传染病诊治国家重点实验室开放基金(2015KF03);国家自然科学基金(81672422);国家重点基础研究发展计划(2013CB531403)

摘　　要：由于肝脏与肠道紧密的解剖与功能关系,肠道微生物通过肝-肠循环和微生态-肝脏轴与宿主相互作用,在肝脏炎症、慢性纤维化及肿瘤发生发展中发挥重要作用。肠道微生态失衡促进肝癌进展,这是国际上实验动物肝癌发病机制的突破性进展。肠道微生物中关键功能菌可能成为肝癌诊治的新型生物标志物和治疗靶点。随着第二代高通量测序技术的发展,元基因组学研究从极大的深度和广度为我们认识肠道菌群与肝癌的关系开辟了新的途径。Due to the close anatomical and functional relationship between the liver and the intestine, intestinal microfh）ra, interact with liver function through the liver-intestinal axis. It plays an important role in the development of the liver inflammation, fibrosis and tumor. Intestinal microflora disorders promote the progress of hepatocellular carcinoma （HCC）, which is an international breakthrough in the pathogenesis of HCC in experimental animals. Key feature strains of the intestinal microflora may become new biomarkers and therapeutic targets of HCC. With the development of the second generation high throughput sequencing technology, the research of metagenomics has opened up a new way for us to understand the relationship between intestinal microflora and HCC from the great depth and breadth.

关 键 词：肠道微生态 肝脏肿瘤 元基因组学 炎-癌转变 整合肝肠病学 

分 类 号：R37[医药卫生—病原生物学] R735.7[医药卫生—基础医学]