育龄女性泌尿生殖道支原体感染及耐药性分析  

Mycoplasma infection of urogenital tract in women at childbearing age and the analysis of drug resistance

作　　者：李秀文[1] 王悦颖[1] 王运铎[1] LI Xiu-wen WANG Yue-ying WANG Yun-duo(Clinical Laboratory,Dalian Center Hospital, Dalian , Liaoning 116033, China)

机构地区：[1]大连市中心医院检验科,辽宁大连116033

出　　处：《中国卫生检验杂志》2016年第20期3016-3018,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的了解本地育龄女性泌尿生殖道支原体感染及耐药性特点,比较不同生育期支原体感染率和耐药性,探讨再育女性孕前支原体检测的意义。方法回顾本院1 135例育龄女性泌尿生殖道标本支原体培养及药敏结果,并将阳性者按生育与否分组,比较2组支原体的感染率和对9种抗菌素的敏感率。结果支原体阳性标本632例,感染率为55.7%。支原体的感染方式分3种:单纯解脲脲原体(Uu)感染率最高,为50.0%;其次为Uu+Mh混合感染,占4.8%;单纯Mh感染率最低,仅占1.0%。单纯Uu感染耐药性较低;Mh及Uu+Mh耐药性较高,仅对美满霉素、强力霉素、交沙霉素较敏感,对罗红霉素、阿奇霉素、克拉霉素高度耐药。已生育组支原体的感染率和耐药性高于未生育组,差异有统计学意义(P<0.05)。结论治疗本地女性支原体感染,应首选美满霉素、强力霉素和交沙霉素,Uu感染也可选择克拉霉素和阿奇霉素;再育女性感染支原体的风险增大,更应重视孕前筛查和规范治疗。Objective To understand the characteristics of infection and drug resistance of mycoplasma in urogenital tract in the local women at childbearing age,and to compare the infection rate and drug resistance of mycoplasma in women at different child- bearing ages,so as to explore the significance of the detection of mycoplasma before pregnancy of the women who procreate for the second time. Methods Retrospectively analyze the results of culture and drug sensitivity in 1 135 cases of mycoplasma in urogenital tract of women at childbearing age in our hospital,and the positive patients were divided into two groups based on bearing or not. The infection rate and the sensitivity rate of mycoplasma to 9 types of antibiotics between the 2 groups were compared. Results There were 632 cases of Mycoplasma positive samples,with the infection rate of 55. 7%; Mycoplasma infections were divided into 3 ways： the infection rate of simple ureaplasma urealyticum（ Uu） was the highest,accounting for50%,followed by Uu and Mycoplasma（ Mh） mixed infection,accounting for 4. 8%,simple Mh infection,only accounting for1. 0%. Simple Uu infection had low drug resistance; and the drug resistance of Mh and Uu ＋ Mh were higher,which were only sensitive to minocycline,doxycycline,josamycin,but highly resistant to roxithromycin,azithromycin,clarithromycin. The infection rate and drug resistance of Mycoplasma of the already bearing group were higher than those of the non fertility group,and the differences had statistical significance（ P 〈 0. 05）. Conclusion Minocycline,doxycycline,and jsamycin should be first chosen in local treatment of mycoplasma infection in female; clarithromycin and azithromycin can be chosen in simple Uu infection too; the risk of mycoplasma infection in the already bearing female is higher. We should pay more attention to the pregnancy screening and standardized treatment.

关 键 词：育龄女性 支原体 耐药性 敏感率 

分 类 号：R375[医药卫生—病原生物学]