不同制法马钱子抗炎镇痛作用研究  

Study on Anti-Inflammatory and Analgesic Effects of Different Processing Products of Strychnos nux-vomica Seeds

作　　者：杨红梅 刘若轩[2] 李丽明[2] 吴菲[2] 李常青[3] 郭洁文[2] YANG Hong-mei LIU Ruo-xuan LI Li-ming WU Fei LI Chang-qing GUO Jie-wen(Guangzhou Women and Children＇s Medical Center, Guangzhou 510170, China Department of Pharmacy, Guangzhou Hospital of Traditional Chinese Medicine, Guangzhou 510130, China Institute of Tropical Medicine, Guangzhou University of Traditional Chi- nese Mdeieine, Guangzhou 510006, China)

机构地区：[1]广州市妇女儿童医疗中心,广东广州510170 [2]广州市中医医院药学部,广东广州510130 [3]广州中医药大学热带医学研究所,广东广州510006

出　　处：《中药材》2016年第6期1276-1278,共3页Journal of Chinese Medicinal Materials

基　　金：广东省中医药局基金(20141225);广州市中医药和中西医结合科技项目(20152A011005;20142A011002);广东省医院药学研究基金(2014A09)

摘　　要：目的:研究油马钱子、砂马钱子和醋马钱子的抗炎镇痛作用差异。方法:分别采用小鼠耳廓肿胀法、醋酸扭体法和小鼠热水甩尾潜伏期影响法研究和比较油马钱子、砂马钱子和醋马钱子的抗炎及镇痛作用。结果:抗炎镇痛实验中,等剂量醋制马钱子抗炎镇痛效果优于油马钱子和砂马钱子。结论:该研究可为优化临床应用马钱子制剂的减毒增效炮制工艺提供理论依据。Objective： To study the differences of anti-inflammatory and analgesic effects between oil,sand and vinegar processing Strychnos nux-vomica seeds. Methods： Mouse auricular swelling and writhing test and mice hot water tail flick latency effect method were used to study and compare the anti-inflammatory and analgesic effects of different processing products of Strychnos nux-vomica seeds. Results： The anti-inflammatory and analgesic effects of vinegar processing Strychnos nux-vomica seeds was better than that of oil and sand processing products. Conclusion： This study can provide theoretical basis for the optimization of processing technology of reducing toxicity and enhancing effects of processed Strychnos nux-vomica seeds.

关 键 词：马钱子 抗炎 镇痛 减毒增效 

分 类 号：R283.1[医药卫生—中药学] R282.5[医药卫生—中医学]