野木瓜化学成分研究  

Chemical Constituents from Stauntonia chinensis

作　　者：张天啸[1,2] 付辉政 杨毅生 王栋 ZHANG Tian-xiao FU Hui-zheng YANG Yi-sheng WANG Dong(Jiangxi Provincial Institute for Drug Control,Jiangxi Provincial Engineering Research Center for Drug and Medical Device Quality, Nanchang 330029 ,China Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China)

机构地区：[1]江西省药品检验检测研究院/江西省药品与医疗器械质量工程技术研究中心,江西南昌330029 [2]江西中医药大学,江西南昌330004

出　　处：《中药材》2016年第7期1554-1558,共5页Journal of Chinese Medicinal Materials

基　　金：江西省自然科学基金(20142BAB205086)

摘　　要：目的：研究野木瓜的化学成分。方法：利用硅胶、ODS、Sephadex LH-20凝胶柱、制备高效液相色谱等色谱方法进行分离纯化,根据理化常数及波谱数据鉴定化合物结构。结果：从野木瓜中分离得到7个化合物,分别鉴定为：3-O-β-D-glucopyranosyl-（1→3）-[β-D-xylopyranosyl-（1→2）]-α-L-arabinopyranosyl-28-O-[α-L-rhamnopyranosyl-（1→4）-β-D-glucopyranosyl-（1→6）-β-D-glucopyranosyl]-3β-hydroxy-30-norolean-12,20（29）-dien-28-oic acid（1）、3-[（O-β-D-glucopyranosyl-（1→3）-[α-L-rhamnopyranosyl-（1→2）]-α-L-arabinopyranosyl）oxy]-30-norolean-12,20（29）-dien-28-oic acid O-β-D-glucopyranosyl-（1→6）-β-D-glucopyranosyl ester（2）、3-O-β-D-[（α-L-xylopyranosyl-（1→2）-O-α-L-arabinopyranosyl）oxy]-30-norolean-12-en-28-oic acidα-L-rhamnopyranosyl-（1→4）-O-β-D-glucopyranosyl-（1→6）-O-β-D-glucopyranosyl ester（3）、野木瓜苷YM27（4）、野木瓜苷YM21（5）、野木瓜苷YM10（6）、野木瓜苷YM7（7）。结论：其中,化合物1~3为首次从野木瓜中分离得到。Objective： To study the chemical constituents of Stauntonia chinensis. Methods： The chemical constituents were isolated and purified by column chromatography on silica gel,ODS,Sephadex LH-20 and MPLC. Their structures were elucidated on the basis of physicochemical properties and special analysis. Results： Seven compounds were isolated from the leaves of Stauntonia chinensis,whose structures were elucidated as 3-O-β-D-glucopyranosyl-（ 1 →3）-[β-D-xylopyranosyl-（ 1 →2） ]-α-L-arabinopyranosyl-28-O-[α-L-rhamnopyranosyl-（ 1 →4）-β-D-glucopyranosyl-（ 1 →6）-β-D-glucopyranosyl]-3β-hydroxy-30-norolean-12,20（ 29）-dien-28-oic acid（ 1）,3-[（ O-β-D-glucopyranosyl-（ 1→3）-[α-L-rhamnopyranosyl-（ 1 →2） ]-α-L-arabinopyranosyl） oxy]-30-norolean-12,20（ 29）-dien-28-oic acid O-β-D-glucopyranosyl-（ 1 → 6）-β-D-glucopyranosyl ester（ 2）,3-O-β-D-[（ α-L-xylopyranosyl-（ 1 → 2）-O-α-L-arabinopyranosyl）oxy]-30-norolean-12-en-28-oic acid α-L-rhamnopyranosyl-（ 1 → 4）-O-β-D-glucopyranosyl-（ 1 → 6）-O-β-D-glucopyranosyl ester（ 3）,yemuoside YM27（ 4）,yemuoside YM21（ 5）,yemuoside YM10（ 6） and yemuoside YM7（ 7）. Conclusion： Compounds 1 ~ 3 are isolated from this plant for the first time.

关 键 词：野木瓜 木通科 化学成分 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]