耳聋蛋白质组学的研究及进展  

The Research and Development of Deafness Proteomics

作　　者：段富家 薛刚[2] 张延平[1] 

机构地区：[1]解放军309医院耳鼻喉科,北京100193 [2]河北北方学院,石家庄075000

出　　处：《中国听力语言康复科学杂志》2016年第6期445-449,共5页Chinese Scientific Journal of Hearing and Speech Rehabilitation

基　　金：北京市自然科学基金面上项目(7142155);2013年全军保健专项课题面上项目(13BJZ24);总参军事医学与老年病科研课题重点项目(ZCWS14B07);全军医学科学技术研究“十二五”计划项目面上项目(CWS11C171)

摘　　要：伴随基因组计划测序的完成、“后基因组时代”的到来，以探索细胞内蛋白质组成及其活动规律为主要内容的蛋白质组学成为热点的研究领域。目前蛋白质组学已经运用到遗传性耳聋、药物性耳聋、老年性耳聋、其他前庭功能听力损害、中耳炎等疾病的研究，本文综述了耳聋蛋白质组学研究方法、最新进展及相关耳科疾病变化的研究，旨在探索各类耳聋的病因、发病机制提供参考。With the completion of the sequencing of the genome project, the arrival of the ＂post genome era＂, proteomics, which is to explore the cellular protein composition and activities of the rules as the main content, has become a hot research area. The proteomics has been applied to the study of genetic deafness, drug deafness, presbycusis, other vestibular, hearing impairment, otitis media disease. This article reviews the deafness proteome science research methods, the latest progress and related changes of ear diseases, aiming toexplore the etiology and pathogenesis of various types of deafness.

关 键 词：耳聋 听觉 蛋白质组学 听力下降 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]