正交试验法优选黄马酊最佳渗漉工艺  

Optimum Percolation Extraction Process of Huang-Ma Tincture by Orthogonal Test Method

作　　者：陈薇[1] 冷静[1] 杨敏[1] 高倩[2] 王琴[1] 

机构地区：[1]重庆市中医院,重庆400021 [2]重庆医科大学药学院,重庆400042

出　　处：《中国药业》2016年第21期37-39,共3页China Pharmaceuticals

摘　　要：目的 优选黄马酊的最佳渗漉提取工艺。方法 选择乙醇浓度（A）、乙醇用量（B）及渗漉速度（C）3个因素为考察对象,以士的宁及盐酸小檗碱的含量为综合评价指标,采用L_9（3～4）正交试验进行优选。结果 以70%乙醇10倍量进行渗漉,渗漉速度为3 m L/（min·kg）为最佳工艺条件。结论 优选得到的黄马酊渗漉工艺合理可行,可用于制剂室大生产。Objective To optimize the percolation extraction process of Huang- Ma Tincture. Methods The Ethanol concentration（A）, Ethanol dosage（B） and percolation rate （C） were selected as the factors, and the contents of Strychnine and Berberine Hydrochloride were taken as the observed index; L9（3^4） orthogonal test was designed to optimize the process. Results The optimal technology was 70% ethanol 10 times as much as that of the drugs and percolation rate was 3 mL/（min · kg）. Conclusion The preparation process is reasonable and highly efficient, which can be used for he mass production of Huang- Ma Tincture.

关 键 词：黄马酊 小檗碱 士的宁 渗漉 正交试验 

分 类 号：R284.2[医药卫生—中药学] R282.71[医药卫生—中医学]