冠心病患者血清脂蛋白a及糖化血红蛋白水平与冠脉Gensini积分的相关性研究  

Correlation study between the level of serum lipoprotein （a） and glycated hemoglobin and the coronary Gensini score in patients with Coronary heart disease （CHD）

作　　者：戴婉如[1] 周欢[1] 伍严安[1] 

机构地区：[1]福建医科大学省立临床医学院,福建福州350001

出　　处：《医学检验与临床》2016年第6期1-3,14,共4页Medical Laboratory Science and Clinics

摘　　要：目的：探讨血清脂蛋白（a）Lp（a）、糖化血红蛋白（HbAlc）与冠心病病变程度的关系。方法：选取50例健康体检者，230例经冠状动脉造影确诊为冠心病的患者，分别测定各组三酰甘油（TG）、胆固醇（TC）、高密度脂蛋白胆固醇（HDL—c）、低密度脂蛋白胆固醇（LDL-C）、栽脂蛋白A（APOA）、载蛋白B（APOB）、脂蛋白（a）fLp（a）1、糖化血红蛋白（HbAlc）、血糖（GLU）的水平，同时应用冠脉造影术（PCI）测定冠心病患者冠脉病变程度（Gensini积分），分析各检测指标水平变化与Gensini积分的相关性。结果：冠心病组血清TG、LP（a）、HbAlc水平明显高于健康对照组，HDL—c明显低于健康对照组，两组间比较有统计学差异（P〈0．05）；而Tc、HDL—c和LDL—c、APoA、APOB、GLU比较无统计学意义（P〉0．05）。LP（a）和HbAlc与Gensini积分呈现正相关性（r=0．186；0．205，P〈0．05），HDL—C与Gensini积分呈现负相关性（r=-0．179，P〈0．05）。经多因素分析显示，LP（a）、HbAlc与Gensini积分存在回归关系（B=0．139，t=2．132，P=-0．034〈0．05；B=O．153，t=2．381，p=-0．018〈0．05）。结论：冠心病患者血清Lp（a）、HbAlc水平与冠脉病变程度呈现正相关，是冠心痛患者Gensini评分的独立危险因素，对冠脉病变有一定的预测价值。Objective： To study the correlations between the levels of lipoprotein（a）[Lp（a）], glycosylated hemoglobin （HbAlc） and the coronary lesion. Methods： 50 healthy subjects were selected as control group, 230 coronary heart disease （CHD） patients diagnosed by coronary angiography were selected as the observation group .The levels of triglyceride （TG）, total cholesterol （TC）, high-density lipoprotein cholesterol（HDL-C）, low density lipoprotein cholesterol（LDL - C）,apolipoprotein A（APOA）, apolipoprotein B（APOB） ,lipoprotein （a） [Lp （a）], glycosylated hemoglobin （HbAlc）,？ glucose（GLL0 were detected respectively in all groups. At the same time, severity （Gensini score） were detected by using coronary angiography. The correlations between the levels of the testing index and severity （Gensini score） were investigated. Results： The levels of TG, LP（a） and HbAlc of CHD group were significantly higher than the control group, HDL - C significantly lower than the control group, the comparison between the two groups was statistically differenent （P 〈 0.05）;and TC, HDL-C, LDL-C, APOA, APOB, GLU is no statistical significance （P〉0.05）.The levels of LP （a） and HbAlc were positiveiy correlated with Gensini score（r=0.186;0.205 , P〈0.05）, HDL - C were negativeiy correlated with Gensini score （r =- 0.179, P〈0.05）. Multivariate analysis showed LP （a） and HbAlc were significanyiy associated with Gensini score （[3=0.139,t=2.132, P=0.034〈0.05 ;[3=0.153,t=2.381, P=0.018〈0.05）. Conclusion ：The levels of Lp （a） and HbAlc of CHD patients were positiveiy correlated with the degree of coronary artery lesions, which were an independent risk factor for CHD patients Gensini score, so we thought they had certain predictive value in coronary lesions.

关 键 词：脂蛋白A 糖化血红蛋白 冠心病 GENSINI积分 

分 类 号：R541.4[医药卫生—心血管疾病]