妥洛特罗对咳嗽变异性哮喘患儿EOS和PEF的影响研究  

Influence study on EOS and PEF in children with cough variant asthma by Toy Lotero

作　　者：吴文红[1] 吴海谊[1] 谢文锐[1] 

机构地区：[1]广东省东莞市人民医院,广东东莞523059

出　　处：《中国医药科学》2016年第17期59-61,共3页China Medicine And Pharmacy

基　　金：广东省东莞市医疗卫生科技计划项目(2014105101201)

摘　　要：目的 对妥洛特罗用于咳嗽变异性哮喘患儿中的EOS与PEF值变化情况进行研究。方法 选择2014年1月~2016年1月我院儿科慢性咳嗽门诊诊治的89例咳嗽变异性哮喘患儿,根据治疗方法不同分为观察组和对照组,观察组43例,对照组46例,对照组予抗组胺药物联合选择性白三烯受体阻滞剂治疗。观察组加用妥洛特罗贴剂于每晚1贴,贴于前胸、后背及上臂部均可,24h更换,连用14d。比较两组治疗后的疗效及两组治疗前后PEF、PEFR的变化。结果 观察组的总有效率达95%,对照组的总有效率为72%,观察组的临床疗效显著优于对照组,两组疗效组间比较差异具有显著性（P〈0.05）。治疗后,两组EOS、PEFR明显降低,PEF明显升高,且观察组EOS、PEF、PEFR较对照组变化更显著（P〈0.05）。结论妥洛特罗用于咳嗽变异性哮喘可以提高临床疗效,改善肺功能,通过降低EOS而发挥抗炎作用。Objective To study the change situation of EOS on and PEF in children with cough variant asthma by Toy Lo Tero. Methods 89 cases of children with cough variant asthma cured in outpatient treatment of cough variant asthma of our hospital from January 2014 to January 2016 were selected. According to the different treatment methods, they were divided into observation group（43 cases）and control group（46 cases）. Patients in control group were treated with antihistamine drugs combined with selective leukotriene receptor antagonist treatment, and patients in observation group were treated with tulobuterol patch（0.5mg/ paste, Nitto denko） every night 1 stick, stick in the chest, back and upper arm can be, 24 h replacement QD for 14 d. The curative effects of the two groups after treatment and the changes of EOS, and PEF, PEFR after treatment in two groups were compared. Results The total effective rate of observation group was 95%, the total effective rate of control group was 72%, the clinical curative effect of observation group was significantly better than that of control group, and the difference between the two groups was significant（P 〈 0.05）. After treatment, the EOS, PEFR of the two groups were significantly decreased, and PEF was significantly increased. The changes of EOS, PEFR and PEF in observation group were more significant than those of control group（P 〈 0.05）. Conclusion The proper treatment of cough variant asthma can improve the clinical efficacy, improve pulmonary function, and exert anti-inflammatory effects by reducing EOS.

关 键 词：咳嗽变异性哮喘 妥洛特罗 EOS PEF 

分 类 号：R725.6[医药卫生—儿科]