血液中褪黑素中毒标记物鉴定（英文）  

Identification of Melatonin Poisoning Markers in Biological Samples by Liquid Chromatography–tandem Mass Spectrometry: Case Report and Analysis

作　　者：张蕾萍[1] 韩旭[2] 杜鸿雁[1] 刘永涛 徐多麒 任昕昕[1] 宋歌[1] 

机构地区：[1]公安部物证鉴定中心,北京100038 [2]天津市公安局物证鉴定中心,天津300384 [3]北京市公安司法鉴定中心,北京100192 [4]中国人民公安大学,北京100038

出　　处：《刑事技术》2016年第5期402-404,共3页Forensic Science and Technology

基　　金：Projects of Key Research(No.201302ZDYJ002);Technical Exchange&Skill Training(B2013001A)

摘　　要：褪黑素是失眠及老年人常用的催眠药之一。近年来,一些犯罪分子利用其为作案工具,从而使之也出现在物证鉴定的检验项目中。本文报道一起涉及褪黑素的麻醉凶杀案的检验鉴定,以原体及代谢物作为中毒标记物,对褪黑素及其代谢物6-羟基褪黑素进行分析检验,并对案件信息作深度挖掘。使用日本岛津30A-LC液相色谱仪串联美国AB SCIEX公司API5500 QTRAP质谱仪,对送检样品进行测定化验,发现受害人血液褪黑素浓度超过正常起催眠作用的浓度达25倍以上。本文建立的液相色谱/串联质谱检验分析,方法简单、快速、有效,效果良好。Melatonin is one of the hypnotics commonly used by the current elderly and people of insomnia. In recent years, melatonin has begun to emerge in drug-facilitated criminal cases since the offenders take it as an auxiliary crime- committing tool. A homicide case involving melatonin has been reported in this paper. The protomer of melatonin and its metabolite 6-hydroxy-melatonin, served as the poisoning markers, were analyzed by ultra high performance liquid chromatography-tandem mass spectrometry （UPLC-MS/MS）, together with the deep mining of the revealed information. The established method is simple, fast and effective in practice. This study should be of great significance in getting more information or details in related cases.

关 键 词：法医毒物分析 褪黑素 6-羟基褪黑素 中毒标记物 液相色谱一质谱 

分 类 号：DF795.1[医药卫生—法医学]