小剂量阿司匹林在不明原因习惯性流产中的应用  

Application of low-dose aspirin in the unexplained habitual abortion

作　　者：傅秀华[1] 刘林丽[1] 林舟[1] 叶健文[1] 林培红[1] 吴铃[1] 

机构地区：[1]福建医科大学附属福州市第一医院妇产科,福建福州350009

出　　处：《中国现代医生》2016年第28期63-65,共3页China Modern Doctor

摘　　要：目的 探讨口服小剂量阿司匹林（Low-dose aspirin,LDA）在不明原因习惯性流产中的治疗效果。方法 选择2012年3月～2015年8月我院妇产科门诊及住院部患者537例作为研究对象,随机分为治疗组（309例）和对照组（228例）,治疗组予LDA抗凝治疗,对照组予口服安慰剂。比较两组孕妇的并发症、妊娠结局及围产儿结局。结果 治疗组临床妊娠率显著高于对照组（68.2%vs 47.8%,P〈0.05）,子痫前期发生率低于对照组（8.5%vs 20.2%,P〈0.05）,差异均有统计学意义;两组妊娠出血性疾病及新生儿结局情况比较,差异无统计学意义。结论 LDA能有效改善不明原因习惯性流产患者的临床妊娠率,不增加妊娠期并发症及新生儿出血性疾病的发生率,但不影响妊娠结局。Objective To investigate the therapeutic effect of low-dose aspirin （LDA） in the treatment of unexplained habitual abortion. Methods 537 outpatients and 537 hospitalized patients from March 2012 to August 2015 were se- lected as research subjects and randomly divided into two groups： the experimental group （309 patients） and the control group（228 patients）. The experiment group was given LDA anticoagulation therapy, while the control group was given oral placebo. The complications, pregnancy outcomes and perinatal outcome in the two groups of pregnant women were observed and compared. Results The clinical rate in the experimental group was significantly higher than that in the control group（68.2% vs 47.8%, P〈0.05）. The incidence rate of preeclampsia was lower than that in the control group （8.5% vs 20.2% P〈0.05）, and the difference was statistically significant. But the hemorrhagic disease of pregnancy and neonatal outcome were not statistically significant. Conclusion LDA is able to effectively improve the clinical pregnancy rate of patients with unexplained habitual abortion, which does not increase incidence of complications during pregnancy and neonatal hemorrhagic disease, and does not affect the outcome of pregnancy.

关 键 词：阿司匹林 习惯性流产 临床妊娠率 围产儿结局 

分 类 号：R714.21[医药卫生—妇产科学]