多层螺旋CT双期扫描与生长抑素受体显像在胰腺内分泌肿瘤诊断中的比较  被引量:15

Comparison of Multislice Spiral CT Dual Phase and Somatosatatin Receptor Scintigraphy in the Diagnosis of Pancreas Neuroendocrine Tumors

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作  者:王辉[1] 李平[2] 潘卫东[2] 薛华丹[2] WANG Hui LI Ping PAN Wei-dong XUE Hua-dan(Department of Radiology, the People' s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000 Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China)

机构地区:[1]新疆维吾尔自治区人民医院放射科,乌鲁木齐830000 [2]中国医学科学院北京协和医学院北京协和医院放射科,北京100730

出  处:《中国医学科学院学报》2016年第3期312-317,共6页Acta Academiae Medicinae Sinicae

基  金:国家自然科学基金(81371608);卫生公益性行业科研专项项目(201402019;201402001)~~

摘  要:目的比较多层螺旋CT双期增强扫描与生长抑素受体显像(SRS)对胰腺神经内分泌肿瘤(p NET)诊断的敏感性。方法收集2012年5月至2015年1月在北京协和医院经病理确诊的28例p NET患者的临床资料,术前均行CT及SRS检查,分析并对比CT双期扫描及SRS对p NET的诊断能力。结果 CT双期扫描和SRS对p NET患者总的诊断敏感性分别为92.8%(26/28)和71.4%(20/28),差异有统计学意义(P=0.031)。对功能性p NET患者的诊断敏感性分别为94.1%(16/17)和58.8%(10/17),差异无统计学意义(P=0.218);对无功能性p NET患者的诊断敏感性分别为90.9%(10/11)和90.9%(10/11),差异无统计学意义(P=0.740)。对无转移p NET患者的诊断敏感性分别为90.4%(19/21)和57.1%(12/21),差异无统计学意义(P=0.125);对合并转移p NET患者的诊断敏感性分别为100%(7/7)和100%(7/7)。对G1级患者的诊断敏感性分别为84.6%(11/13)和53.8%(7/13),对G2级患者的诊断敏感性分别为100%(12/12)和83.3%(10/12),对G3级患者的诊断敏感性分别为100%(3/3)和100%(3/3)。CT双期扫描和SRS对病灶直径≤2.0 cm的p NET诊断敏感性分别94.7%(18/19)和52.6%(10/19),差异有统计学意义(P=0.008);CT双期扫描和SRS对病灶直径>2.0 cm的p NET诊断敏感性分别为92.8%(13/14)和100%(14/14)。结论 CT双期扫描对p NET患者的诊断敏感性高于SRS。p NET患者的病理分级越低,CT双期扫描与SRS相比优势越明显。对于直径≤2.0 cm的病灶,SRS容易出现假阴性,需同时结合其他影像学检查。Objective To compare the sensitivity of muhislice spiral CT dual phase and somatosatatin receptor scintigraphy (SRS) in the diagnosis of pancreas nuroendocrine tumors (pNET) . Methods Totally 28 patients with pathologically confirmed pNET reeieved both CT dual phase contrast and SRS and the results were compared. Results Of these 28 pNET patients, 26 (92. 8% ) were accurately diagnosed by CT dual-phase scan and 20 (71.4%) by SRS (P = 0. 031 ) . In the functioning pNET cases, the diagnosis sensitivity of CT dual phase scan and SRS was 94.1% (16/17) and 58.8% (10/17) (P = 0. 218) . In the non-functioning pNET cases, the sensitivity was 90.9% ( 10/11 ) and 90.9% ( 10/11 ) (P = 0.740) . Diagnostic sensitivity of CT dual phase scan and SRS for pNET without metastasis was 90.4% ( 19/21 ) and 57.1% ( 12/21 ) (P = 0. 125). The sensitivity for pNET with metastasis was 100% (7/7) and 100% (7/7) . Corresponding to the pathological grading, the diagnostic sensitivity of CT dual phase scanning and SRS was 84.6% (11/13) and53.8% (7/13) forG1, 100% (12/12) and83.3% (10/12) for G2, and 100% (3/3) and 100% (3/3) for G3. The diagnostic sensitivity of CT dual phase scan and SRS for pNET with diameter less than or equal to 2.0 cm was 94.7% (18/19) and 52.6% (10/19) (P = 0. 008 ) . For pNET with diameter more than 2.0 cm, the sensitivity was 92.8% (13/14) and 100% (14/14) . Conclusions Compared with SRS, dual phase CT scan is more sensitive in diagnosing pNET, especially for those in lower pathological sta- ges. For lesions sized less than or equal to 2.0 cm, SRS should be combined with other imaging examinations to minimize false negative results.

关 键 词:CT双期扫描 生长抑素受体显像 胰腺内分泌肿瘤 

分 类 号:R814.4[医药卫生—影像医学与核医学]

 

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