超声辅助蒙脱土负载碘催化Knoevenagel反应  

Knoevenagel Reaction Catalyzed by I_2 Loaded Montmorillonite under Ultrasonic Conditions

作　　者：尹晓刚[1] 吴小云[1] 王野[1] 陈治明[1] 陈卓[1] 

机构地区：[1]贵州师范大学化学与材料科学学院贵州省功能材料化学重点实验室,贵州贵阳550001

出　　处：《化学试剂》2016年第11期1036-1040,1044,共6页Chemical Reagents

基　　金：国家自然科学基金资助项目(21362006);贵州省科技厅科技合作项目(黔科合LH字[2016]7218);贵州省科技厅科技支撑项目(黔科合支撑[2016]2311)

摘　　要：采用超声辅助法,将蒙脱土负载分子碘作为催化剂,进行Knoevenagel反应。通过单因素法探究了催化剂、溶剂、碱添加剂对产率的影响。正交实验法优化反应时间、温度及原料物质的量比,并通过红外、核磁、熔点分析方法对产物进行表征。结果表明,在最优反应条件下产率可达95.5%,蒙脱土与分子碘具有协同催化效果,且有一定的循环使用能力。An ultrasound-assisted Knoevenagel reaction catalyzed by I2 loaded montmorillonite was developed using malonitrile and aromaticaldehyde as starting materials. The influences of solvents and catalysts on yields were investigated using single factor methods and the temperature,ultrasonic time,quivalency of starting materials were screened using orthogonal tests. The products were confirmed by1 HNMR,m. p. and IR. Yields up to 95. 5% under the optimized conditoins. Montmorillonite and molecular iodine has a synergistic catalytic effect which have general circulation capability.

关 键 词：蒙脱土 I2 超声 KNOEVENAGEL反应 

分 类 号：O621.3[理学—有机化学]