CKD-EPI方程和Gate’s法在测量高龄老年人肾小球滤过率的适用性比较  

Comparison of the Estimation on Glomerular Filtration Rate between Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI)Equation and Gate's Equation

作　　者：张庆[1] 王淑侠[1] 刘恩涛[1] 梁嘉伟[1] 

机构地区：[1]广东省人民医院核医学科广东省医学科学院,广州510080

出　　处：《循证医学》2016年第5期305-309,共5页The Journal of Evidence-Based Medicine

摘　　要：目的探讨联合肌酐和胱抑素C的慢性肾脏病流行病合作组方程和Gate’s法计算高龄(年龄≥80岁)老年人肾小球滤过率的适用性。方法收集99例一般高龄老年人的临床资料,以双血浆法所测得肾小球滤过率为标准,分别用慢性肾脏病流行病合作组方程和Gate’s法计算肾小球滤过率,比较两者的估计偏差、精确性、准确性和95%的一致性。结果慢性肾脏病流行病合作组方程比Gate’s法降低了偏差(P=0.000),提高了精确度,15%、30%和50%准确性(P=0.000、0.000、0.004)以及95%一致性,差异有统计学意义。结论对于高龄老年人,在不需要了解双肾形态、血流灌注状态及单侧肾功能的情况下,慢性肾脏病流行病合作组方程可能是较好的选择。Objective To compare the applicability of the combined creatinine-cystatin C equation （CKD-EPLscr-cys）of the Chronic Kidney Disease Epidemiology Collaboration （CKD-EPI） and the Gate＇ s equation based on the renal dynamic imaging for estimating glomerular filtration rate （GFR） among the elderly patients （age≥80 years old）. Methods The GFR of 99 patients at the age of 80 and over were measured by the two-sample method and as standard. Then, Chronic Kidney Disease Epidemiology Collaboration equation and Gate＇ s equation were used to determine GFR simultaneously the differences of the two equations in deviation, accuracy, veracity and consistency of GFR prediction. Results Compared with the Gate＇ s equation, Chronic Kidney Disease Epidemiology Collaboration equation reduce the deviation （P=0.000） , improve the accuracy, 15%, 30% and 50% veracity （P=0.000, 0.000, 0.004） and 95% consistency with statistically significant difference. Conchmiom Chronic Kidney Disease Epidemiology Collaboration equation might be a better method to evaluate the GFR of elders without measuring the parameter of morphology and hemodynamics and unilateral renal function.

关 键 词：肾小球滤过率 CKD-EPI方程 Gate’s法 肌酐 胱抑素C 

分 类 号：R692[医药卫生—泌尿科学] R334.1[医药卫生—外科学]