心脏心房利尿钠肽转换酶在妊娠期高血压疾病发病机制中的作用研究  

The role of cardiac Corin enzyme in the pathogenesis of pregnancy induced hypertension

作　　者：杨建梅 赵丹阳 李建华 YANG Jian - mei ZHAO Dan - yang LI Jian - hua(Department of Obstetrics and Gynecology, the People＇s Hospital of Urumqi Autonomous Region, Urumqi Xinjiang 830054, P. R. Chin)

机构地区：[1]乌鲁木齐市自治区人民医院北院妇产科,新疆乌鲁木齐市830054

出　　处：《中国计划生育和妇产科》2016年第11期34-37,共4页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的探讨心房利尿钠肽转换酶(Corin)在妊娠期高血压疾病(hypertension disorders in pregnancy,HDP)发病中的作用,为HDP防治寻找潜在的防治靶点。方法收集乌鲁木齐市自治区人民医院北院2014年1月至2016年2月住院的HDP患者94例(HDP组),其中妊娠期高血压15例、轻度子痫前期34例、重度子痫前期32例、子痫13例。选取同期产检的正常产妇40例作为正常对照组。Corin酶的测定使用ELISA法。66例子痫前期患者根据随机数字法分为常规治疗对照组和丹红治疗研究组,每组33例。比较治疗后两组Corin表达、分娩时孕周、新生儿体重、围产儿死亡率、孕产妇死亡率和剖宫产率。结果正常对照组Corin酶表达水平为(186.4±31.7)pg/m L,显著高于HDP组的(142.4±19.5)pg/m L(P<0.05)。妊娠期高血压组、轻度子痫前期组、重度子痫前期组和子痫组中Corin表达水平分别为(167.2±25.3)pg/m L、(151.4±20.1)pg/m L、(132.3±18.2)pg/m L和(115.7±14.6)pg/m L,4组间差异有统计学意义(P<0.05)。常规治疗对照组和丹红治疗研究组在丹红治疗前Corin酶和24 h尿蛋白各项指标差异无统计学意义(P>0.05),经丹红治疗后丹红治疗研究组Corin酶的升高和24 h尿蛋白减低显著优于常规治疗对照组(P<0.05)。丹红治疗研究组的分娩时孕周、新生儿体重[(33.8±2.6)周、(1 792.5±224.2)g]显著优于常规治疗对照组[(32.4±2.4)周、(1 650.4±217.3)g](P<0.05)。丹红治疗研究组围产儿死亡率为0%,孕产妇死亡率为0%,剖宫产率为90.9%,与常规治疗对照组的3.0%、0%和93.9%比较差异无统计学意义(P>0.05)。结论 HDP孕妇体内存在Corin酶的异常低表达,丹红注射液可以显著升高Corin酶的表达,延长HDP孕周,增加新生儿体重,降低孕妇尿蛋白。Objective To investigate the role of cardiac Corin enzyme in the pathogenesis of hypertension disorders in pregnancy （HDP）. Methods 94 HDP patients in People＇s Hospital of Urumqi Autonomous Region from January 2014 to February 2016 were collected, which included 15 cases of gestational hypertension, 34 cases with mild preeclampsia, 32 cases of severe preeclampsia, and 13 cases of eclampsia. Another 40 cases of normal maternal were selected as normal control. The Corin was determined by ELISA analysis. 66 cases of preeclampsia patients were randomly divided into Danhong study group and conventional therapy control group, 33 cases in each group. The expression of Corin, delivery week, neonatal birth weight, perinatal mo^lity rate, maternal mortality rate and the rate of cesarean section were compared. Results The expression level of Corin in normal control group was （ 186.4 ± 31.7） pg/mL, which was higher than that of （ 142. 4± 19. 5） pg/mL in HDP group （P 〈0. 05） . The expression level of Corin in gestational hypertension, mild preeclampsia, severe preeclampsia, and eclampsia group were （167.2 ±25.3） pg/mL, （151.4±20. 1 ） pg/mL, （ 132. 3 ± 18. 2） pg/mL, and （ 115.7 ± 14. 6） pg/mL. There were significant differences among the four groups （P 〈 0. 05 ）. After Danhong treatment, the increase of Corin and reduction of 24h urinary protein was significantly higher in Danhong study group than that in conventional therapy control group （P 〈 0. 05）. The gestational week was （33.8 ± 2. 6） weeks in Danhong study group, which was significantly longer than that of （ 32.4 ± 2.4） weeks in conventional therapy control group （ P 〈 0.05 ）. Neonatal weight was （ 1792. 5 ± 224. 2）g in Danhong study group, which was significantly higher than that of （1650. 4 ±217.3 ）g in conventional therapy control group （P 〈0. 05）. The perinatal mortality rate was 0%, the maternal mortality rate was 0%, the rate of cesarean section was 90. 9% in Danhong study group

关 键 词：心房利尿钠肽转换酶(Corin) 妊娠期高血压疾病 丹红注射液 

分 类 号：R714.24[医药卫生—妇产科学]