围产期B族链球菌感染妇女进行产时抗菌素预防性治疗情况分析  

Analysis on intrapartum antibiotic prophylactic treatment among group B streptococcus-infected women during perinatal period

作　　者：陆少颜[1] 徐烨[1] 陈泳言[1] 潘健儿[1] 

机构地区：[1]江门市妇幼保健院检验科,广东江门529000

出　　处：《中国妇幼保健》2016年第22期4653-4655,共3页Maternal and Child Health Care of China

基　　金：2014年江门市科技局第四批科技计划项目(江科2014-74号)

摘　　要：目的探讨江门地区围产期B族链球菌(GBS)感染妇女进行产时抗菌素预防性治疗的情况,以降低本地区围产期妇女GBS感染相关疾病的发生率。方法回顾性分析2014年3月-2015年2月在产时进行抗菌素预防性治疗的226例GBS感染孕妇和2010年1月-2013年7月在产时未进行抗菌素预防性治疗的47例GBS感染孕妇的临床资料,比较两组胎儿窘迫、胎膜早破、产前发热、绒毛膜羊膜炎和羊水浑浊等GBS感染相关疾病的发生率。结果两组GBS感染孕妇胎儿窘迫、产前发热和绒毛膜羊膜炎等GBS感染相关疾病的发生率比较,差异均有统计学意义(P<0.001),胎膜早破及羊水浑浊的发生率比较,差异均无统计学意义(P>0.05);产时抗菌素预防性治疗中,使用青霉素167例(73.9%)、头孢唑啉41例(18.1%)、头孢呋辛6例(2.79%)、阿奇霉素4例(1.8%)、克林霉素1例(0.4%)、头孢西丁7例(3.1%)。结论 GBS感染孕妇应进行产时预防性治疗,青霉素是预防GBS感染的首选药物,产时进行抗菌素预防性治疗能有效减少孕妇GBS感染相关疾病的发生。Objective To explore intrapartum antibiotic prophylactic treatment among group B streptococcus （GBS） -infected women during perinatal period to reduce the incidence rate of GBS infectiori related diseases among perinatal women in this region. Methods The clinical data of 226 GBS-infected pregnant women treated by intrapartum antibiotic prophylactic therapy from March 2014 to February 2015 and 47 226 GBS-infected pregnant women without intrapartum antibiotic prophylactic therapy was analyzed retrospectively. The incidence rates of GBS infection related diseases, such as fetal distress, premature rupture of fetal membrane （ PROM）, prenatal fever, chorioamnion- itis, and amniotie fluid turbidity, were compared between the two groups. Results There were statistically significant differences in the inci- dence rates of GBS infection related diseases, such as fetal distress, prenatal fever, ehorioamnionitis, between the two groups （P〈0. 001 ）, but there was no statistically significant difference in the incidence rates of PROM and amniotie fluid turbidity between the two groups （P〉 0. 05 ） ; the drugs used among the GBS-infected pregnant treated by intrapartum antibiotic prophylactic therapy included penicillin （ 167 ca- ses, 73.9% ）, cefazolin （41 cases, 18. 1% ）, cefuroxime （6 cases, 2.79% ）, azithromyein （4 cases, 1.8% ）, elindamycin （ 1 case, 0.4% ）, cefoxitin （7 eases, 3.1% ） . Conclusion GBS-infected pregnant women should apply intrapartum preventive treatment, the first choice is penicillin, intrapartum antibiotic prophylactic treatment can effectively reduce the incidence rates of GBS infection related diseases.

关 键 词：围产期妇女 GBS感染 产时抗菌素预防性治疗 

分 类 号：R714.7[医药卫生—妇产科学]