卡前列素氨丁三醇不同给药方式治疗产后出血的临床疗效与安全性分析  

Analysis on clinical effects and safeties of carboprost tromethamine of different administration modes in treatment of postpartum hemorrhage

作　　者：林兴喆 徐慧群 杨剑辉 

机构地区：[1]厦门市妇幼保健院药学部,福建厦门361003 [2]厦门市妇幼保健院产房,福建厦门361003

出　　处：《中国妇幼保健》2016年第22期4660-4662,共3页Maternal and Child Health Care of China

摘　　要：目的评价肌肉注射和宫颈注射卡前列素氨丁三醇两种方式治疗产后出血的临床疗效。方法将460例产后出血患者,随机分为对照组318例与实验组142例。对照组手臂三角肌肌肉注射卡前列素氨丁三醇注射液250μg,而实验组宫颈注射相同剂量的卡前列素氨丁三醇注射液。比较对照组与实验组患者在第三产程结束后2 h内子宫出血量、阴道出血量以及产后不良反应率。结果实验组子宫出血量平均为(71.43±13.96)ml,对照组的子宫出血量为(50.56±10.78)ml,两组比较有统计学差异(P<0.05);实验组的阴道出血量(35.31±6.32)ml,对照组的阴道出血量(44.27±8.31)ml,两组比较有统计学差异(P<0.05);实验组不良反应发生率为16.12%,对照组不良反应发生率为11.66%,两组间无统计学差异(P>0.05)。结论子宫收缩乏力产妇建议采取手臂三角肌肌肉注射预防和治疗产后出血;其他类型产妇建议采取宫颈注射预防产后出血。Objective To evaluate the clinical effects of intramuscular and cervical injection of carboprost tromethamine in treatment of postpartum hemorrhage. Methods A total of 460 patients were randomly divided into control group （318 cases） and experimental group （142 cases） . The cases in control group were treated by intramuscular injection of carboprost tromethamine （250 μg） , while the cases in experimental group were treated by cervical injection of earboprost tromethamine （250 μg） . The amounts of endometrorrhagia and colpor- rhagia within 2 hours after the end of the third stage of labor and the incidence rates of adverse reactions in the two groups were compared. Results The amounts of endometrorrhagia in experimental group and control group were （71.43 ± 13.96 ） ml and （50. 56±10. 78 ） ml, respectively （P〈0. 05） ; the amounts of colporrhagia in experimental group and control group were （35.31±6. 32） ml and （44. 27±8. 31 ） ml, respectively （P〈0. 05 ） ; the incidence rates of adverse reactions in experimental group and control group were 16. 12% and 11.66%, respectively （ P〉0. 05） . Conclusion It is recommended to treat uterine inertia patients by intramuscular injection to prevent and treat post- partum hemorrhage; cervical injection Should be selected to prevent postpartum hemorrhage among the patients with other causes.

关 键 词：卡前列素氨丁三醇 肌肉注射 宫颈注射 产后出血 

分 类 号：R714.461[医药卫生—妇产科学]