依达拉奉联合尼莫地平对颅脑损伤患者氧化应激、炎症因子的影响  

Effect of edaravone combined with nimodipine on oxidative stress,inflammatory factors in patients with craniocerebral injury

作　　者：解晓燕[1] 李旭[2] 宋江庆[3] 

机构地区：[1]河南省南阳市第二人民医院神经外科监护室,河南南阳473000 [2]河南省南阳市第二人民医院医务科,河南南阳473000 [3]河南省南阳市第二人民医院药学部,河南南阳473000

出　　处：《海南医学院学报》2016年第21期2527-2529,2534,共4页Journal of Hainan Medical University

基　　金：河南省医学科技攻关项目(2015010028)~~

摘　　要：目的:观察依达拉奉联合尼莫地平对颅脑损伤患者氧化应激、炎症因子的影响。方法:将126例颅脑损伤病例随机分为观察组(66例)和对照组(60例)。对照组在常规治疗的基础上给予尼莫地平,观察组在对照组的基础上给予依达拉奉。治疗14d,观察两组氧化应激指标(SOD、MPO、MDA)、炎症因子(CRP、TNF-α、IL-8)的变化。结果:(1)两组SOD、MPO、MDA水平比较差异有统计学意义(P<0.05),两组MPO、MDA、LPO随着时间的延长表现出先升高后降低的趋势(P<0.05),观察组SOD升高的幅度大于对照组而MPO、MDA升高的幅度小于对照组(P<0.05);(2)两组TNF-α、CRP、IL-8水平比较差异有统计学意义(P<0.05),两组TNF-α、CRP、IL-8随着时间的延长表现出先升高后降低的趋势(P<0.05),观察组升高的幅度小于对照组(P<0.05)。结论:依达拉奉联合尼莫地平应用于颅脑损伤时抑制氧化应激、炎症反应作用显著,优于单用尼莫地平。Objective：To observe the effect of edaravone combined with nimodipine on oxidative stress,inflammatory factors in patients with craniocerebral injury.Methods：A total of 126 patients with craniocerebral injury were randomly divided into the observation group （66 cases）and the control group （60 cases）.The control group was given nimodipine based on con-ventional therapy,and the observation was given edaravone based on the control group.For 14 days,the changes of oxidative stress indicators （SOD,MPO,MDA）and inflammatory factors （CRP,TNF-α,IL-8）between the two groups were observed. Results：There was significantly difference in SOD,MPO,MDA in these two groups （F g r o u p =5.483,6.275,6.561,P 〈0.05）, they were all showed a rising then reducing trend over time （F t i m e =13.062,8.1 72,7.842,P 〈0.05）,the rising amplitude of＆nbsp;SOD in observation group was less than the control group and MPO,MDA was more than the control group （F i n t e r a c t i o n =5.305,4.631,5.327,P 〈0.05）.There was significantly difference of TNF-α,CRP,IL-8 in these two groups （F g r o u p =9.308, 10.375,1 1.350,P 〈0.05）,they were all showed a rising then reducing trend over time （F t i m e =9.308,10.375,1 1.350,P 〈0.05）,the rising amplitude in observation group was less than the control group （F i n t e r a c t i o n =5.071,4.736,6.347,P 〈0.05）. Conclusions Edaravone combined with nimodipine can inhibits oxidative stress and inflammatory reaction significantly in cranio-cerebral injury,and better than nimodipine alone.

关 键 词：颅脑损伤 依达拉奉 尼莫地平 氧化应激 炎症因子 

分 类 号：R651.15[医药卫生—外科学]