复方α酮酸辅助治疗对早期糖尿病肾病患者血清肾功能指标以及营养状态的影响  

Effect of adjuvantα-keto acid therapy on serum renal function indexes and nutritional status in patients with early diabetic nephropathy

作　　者：张敏 王璐[2] 

机构地区：[1]陕西省宝鸡市眉县人民医院,陕西宝鸡722300 [2]延安大学医学院,陕西延安716000

出　　处：《海南医学院学报》2016年第21期2558-2561,共4页Journal of Hainan Medical University

基　　金：陕西省卫生厅卫生科研基金项目(2010H24)~~

摘　　要：目的:分析复方α酮酸辅助治疗对早期糖尿病肾病患者血清肾功能指标以及营养状态的影响。方法:86例早期糖尿病肾病患者分为观察组及对照组,对照组接受常规治疗,观察组接受常规+复方α酮酸辅助治疗,对比两组患者的治疗2月后血清肾功能指标、营养指标、血管内皮功能指标、微炎症指标等差异。结果:观察组患者的血清肾功能指标UAER水平,BUN、SCr、CysC、β2-MG含量低于对照组患者,GFR水平高于对照组患者;营养指标ALB、PA、Hb含量高于对照组患者,nPCR水平低于对照组患者;血管内皮功能指标NO、CGRP含量高于对照组患者,ET-1、MCP-1、resistin含量低于对照组患者;微炎症指标hs-CRP、IL-1β、IL-17、IL-22、TGF-β1、SAA含量低于对照组患者。结论:复方α酮酸辅助治疗有助于提升早期糖尿病肾病患者的肾功能及营养状态,在优化整体治疗效果方面具有正面意义。Objective：To analyze the effect of adjuvant α-keto acid therapy on serum renal function indexes and nutri-tional status in patients with early diabetic nephropathy.Methods：A total of 86 patients with early diabetic nephropathy were divided into observation group and control group,control group received conventional therapy,observation group received con-ventional therapy ＋ adjuvantα-keto acid therapy,and then differences in serum renal function indexes,nutrition index,vascu-lar endothelial function indexes,micro-inflammation indexes and so on were compared between two groups of patients after 2 months of treatment.Results：Serum renal function indexes UAER level as well as BUN,SCr,CysC andβ2-MG content of ob-servation group was lower than those of control group while GFR level was higher than that of control group;nutrition indexes ALB,PA and Hb content were higher than those of control group while nPCR level was lower than that of control group;vas-cular endothelial function indexes NO and CGRP content were higher than those of control group while ET-1,MCP-1 and re-sistin content were lower than those of control group;micro-inflammation indexes hs-CRP,IL-1β,IL-1 7,IL-22,TGF-β1 and SAA content were lower than those of control group.Conclusions：Adjuvant α-keto acid therapy helps to improve the renal function and nutritional status of patients with early diabetic nephropathy,and has positive significance in optimizing the overall treatment effect.

关 键 词：早期糖尿病肾病 复方Α酮酸 肾功能 营养状态 

分 类 号：R587.2[医药卫生—内分泌]