替罗非班联合氯吡格雷对急性心肌梗死患者血清炎症因子及凝血功能的影响  

Effect of tirofiban combined with clopidogrel on serum inflammatory factors and coagulation functions in patients with acute myocardial infarction

作　　者：胡菁[1] 金超英[1] 周云芳[1] 

机构地区：[1]武汉科技大学医院心血管神经内科,湖北武汉430065

出　　处：《海南医学院学报》2016年第21期2599-2601,2604,共4页Journal of Hainan Medical University

基　　金：湖北省科技攻关计划(2013BC102B17-3)~~

摘　　要：目的:观察替罗非班联合氯吡格雷对急性心肌梗死(AMI)患者血清炎症因子及凝血功能的影响。方法:106例AMI病例随机分为观察组(55例)和对照组(51例)。对照组在常规治疗的基础上给予氯吡格雷,观察组在对照组的基础上给予替罗非班。治疗2周,观察两组炎症因子(TNF-α、hs-CRP、IL-6、P-selectin)及凝血功能(PT、TT、APTT)的变化。结果:(1)治疗后,两组TNF-α、hs-CRP、IL-6及P-selectin均明显下降(P<0.05),且观察组治疗后TNF-α、hs-CRP、IL-6及P-selectin水平分别为(2.75±1.53)ng/L、(2.23±1.48)mg/L、(6.34±2.25)ng/mL、(8.21±2.45)ng/mL,均显著低于对照组治疗后,同期比较差异有统计学意义(P<0.05);(2)治疗后,两组PT、APTT、TT较明显延长(P<0.05),且观察组治疗后PT、TT、APTT分别为(14.35±1.68)s、(27.21±4.13)s、(26.32±3.19)s,显著大于对照组治疗后,同期比较差异有统计学意义(P<0.05);(3)两组不良反应无明显差异(P>0.05)。结论:替罗非班联合氯吡格雷应用于AMI时抑制炎症反应、调节凝血功能作用更为显著,优于单用氯吡格雷。Objective：To observe the effect of tirofiban combined with clopidogrel on serum inflammatory factors and coagulation functions in patients with acute myocardial infarction （AMI）.Methods：A total of 106 patients with AMI were se-lected and randomly divided into observation group （55 cases）and control group （5 1 cases）.The control group was given clopi-dogrel based on conventional therapy,and the observation was given tirofiban based on the control group.For 2 weeks,the changes of serum inflammatory factors （TNF-α,hs-CRP,IL-6,P-selection）and coagulation functions （PT,TT,APTT）be-tween the two groups were observed.Results：After treatment,TNF-α,hs-CRP,L-6 and P-selection levels in the two group both decreased compared with that before treatment （P 〈0.05）,TNF-α,hs-CRP,L-6 and P-selection levels in the observation group were decreased more significantly than that in the control group （P 〈0.05）.After treatment,PT,TT and APTT levels in the two group both extended compared with that before treatment （P 〈0.05）,PT,TT and APTT levels in the observation＆nbsp;group were improved more significantly than that in the control group （P 〈0.05 ）.There was no significant difference in ad-verse reactions between the two groups （P 〈0.05）.Conclusions：Tirofiban combined with clopidogrel could restrain inflamma-tory response and regulate coagulation functions more significant in patients with AMI,and better than that of using clopi-dogrel alone.

关 键 词：急性心肌梗死 替罗非班 氯吡格雷 炎症因子 凝血功能 

分 类 号：R542.22[医药卫生—心血管疾病]