硫酸镁联合硝苯地平对妊娠期高血压患者血流动力学和尿蛋白水平的影响  

Effect of the combination of magnesium sulfate and nifedipine on hemodynamics and urinary protein levels of patients with gestational hypertension

作　　者：牛玉伟[1] 刘荃[1] 王宏宇[1] 

机构地区：[1]安徽省合肥市第一人民医院妇产科,安徽合肥230061

出　　处：《海南医学院学报》2016年第23期2873-2875,2879,共4页Journal of Hainan Medical University

基　　金：安徽省卫生厅科学研究项目(2015B199Y)~~

摘　　要：目的：探讨硫酸镁联合硝苯地平对妊娠期高血压患者血流动力学和尿蛋白水平的影响。方法：选择2013年12月-2015年9月本院收治的100例妊娠期高血压患者为研究对象,平均分为对照组和观察组,各50例。对照组单独采用硫酸镁治疗,观察组在对照组的基础上联合硝苯地平治疗。治疗前后分别对两组患者的血流动力学指标和尿蛋白水平进行比较。结果：治疗前,两组患者的收缩压、舒张压、全血粘度（高切、中切和低切）和全血还原黏度（高切、中切和低切）比较均无显著差异（均P〉0.05）;治疗后,两组患者的舒张压、全血粘度（高切、中切和低切）和全血还原黏度（高切、中切和低切）指标较治疗前均显著降低（均P〈0.05）,且观察组的上述指标均显著低于对照组（均P〈0.05）,差异具有统计学意义（P〈0.05）。治疗前,两组患者的24h尿蛋白、尿钙黏蛋白和尿激肽原1（KNG1）水平比较均无显著差异（均P〉0.05）,不具有统计学意义;治疗后,两组患者的24h尿蛋白、尿钙黏蛋白和KNG1水平较治疗前均显著降低（均P〈0.05）,且观察组24h尿蛋白、尿钙黏蛋白和KNG1水平均显著低于对照组（均P〈0.05）,差异具有统计学意义（P〈0.05）。结论：硫酸镁联合硝苯地平治疗可有效改善妊娠期高血压患者的临床症状、降低血液黏度,疗效显著,值得临床推广。Objective：To investigate the effects of the combination of magnesium sulfate and nifedipine on hemodynamics and urinary protein of patients with gestational hypertension.Methods：A total of 100 patients with gestational hypertension admitted to our hospital were divided into control group（n=50patients）and experimental group（n=50patients）.The control group was only treated with magnesium sulfate,the experimental group was also given the combination with nifedipine based on treatment of the control group.The modynamics and urinary protein of patients of two groups before and after treatment were compared.Results：Before the treatment,diferences in systolic blood pressure（SBP）,diastolic blood pressure（DBP）,whole blood viscosity（WBV）（high shear,shear and low shear）and the reduced viscosity of whole blood（WBRV）（high cut,cut and low cut）shows no significant difference（P〉0.05）.After the treatment,these parameters of the twogroups were obviously decreased（P〈0.05）.The difference was statistically significant（P〈0.05）.Before the treatment,there was no statistically significant difference in 24 hproteinuria,urinary cadherin,and urinary kininogen-1（KNG1）between these two groups of patients（P〉0.05）.But after the treatment,24 hproteinuria,urinary cadherin,and KNG1 of the two groups were statistically significantly lower than that before treatment（P〈0.05）.Moreover,the experimental group shows24 hproteinuria,urinary cadherin,and KNG1 respectively of（472.82±35.45）mg/24 h,（2.36±0.87）mg/L,and（445.06±106.43）mg/L which were significantly lower than that of the control group（P〈0.05）.Conclusions：The combination of magnesium sulfate and nifedipine is effectively in improving clinical symptoms in patients with gestational hypertension,it also helps to reduce blood viscosity.Thus,this combination treatment should be promoted widely.

关 键 词：妊娠期高血压 硫酸镁 硝苯地平 血流动力学 尿蛋白 

分 类 号：R714.252[医药卫生—妇产科学]