丹参注射液对妊娠高血压综合征患者氧化应激及炎性因子的影响  

Effect of Danshen injection on the oxidative stress and inflammatory cytokines in patients with pregnancy-induced hypertension syndrome

作　　者：张俊清[1] 高巍[1] 

机构地区：[1]河北北方学院附属第二医院,河北张家口075000

出　　处：《海南医学院学报》2016年第23期2880-2882,共3页Journal of Hainan Medical University

基　　金：河北省张家口市科学技术研究与发展指导项目(1421105D)~~

摘　　要：目的：探讨丹参注射液对妊娠高血压综合征（PIH）患者氧化应激及炎性因子的影响。方法：选取2015年6月-2016年6月收治的PIH患者100例为研究对象,随机分为观察组和对照组（n=50）,对照组给予降压、利尿、解痉、镇静、硫酸镁等常规治疗,并进行综合护理干预,观察组在对照组基础上联合丹参注射液20mL入5%葡萄糖500mL静脉滴注,1次/d,两组治疗10d后进行效果评价;两组治疗前后分别采集外周静脉血,采用硝酸还原法测定血浆一氧化氮（NO）,采用硫代巴比妥酸法测定丙二醛（MDA）,采用黄嘌呤氧化酶法测定超氧化物歧化酶（SOD）,采用酶联免疫吸附法测定血清高迁移率蛋白-1（HMGB1）,采用免疫比浊法测定血清半胱氨酸蛋白酶抑制剂C（Cys C）,分光光度计测定血清同型半胱氨酸（Hcy）,并监测心率（HR）和平均动脉压（MAP）。结果：观察组治疗后NO、SOD、MDA改善程度优于对照组（P〈0.05）,观察组治疗后HMGB1、Hcy、Cys C改善程度优于对照组（P〈0.05）,观察组治疗后MAP改善程度优于对照组（P〈0.05）。结论：在常规治疗及综合护理干预下联合丹参注射液治疗PIH,可通过调控氧自由基而改善氧化应激及炎性反应,实现降低血压的目的。Objective：To explore the effect of Danshen injection on the oxidative stress and inflammatory cytokines in patients with pregnancy-induced hypertension syndrome（PIH）.Methods：A total of 100 patients with PIH who were admitted in our hospital were included in the study and randomized into the observation group and the control group（n=50）.The patients in the control group were given blood pressure reduction,diuresis,spasmolysis,sedation,magnesium sulfate,and comprehensive nursing intervention.On this basis,the patients in the observation group were given additional Danshen injection（20mL）＋ 5% glucose（250mL）,ivdrip,1time/d.After 10-day treatment,the efficacy was evaluated.The peripheral venous blood before and after treatment in the two groups was collected.The nitric acid reduction method was used to detect the plasma NO.TBA method was used to detect MDA.XOD method was used to detect SOD.ELISA was used to detect the ser-um HMGB1.Immunoturbidimetric assay was used to detect the serum Cys C.The spectrophotometer was used to detect the serum Hcy.HR and MAP were monitored.Results：The improved degree of NO,SOD,and MDA after treatment in the observation group was significantly superior to that in the control group（P〈0.05）.The improved degree of HMGB1,Hcy,and Cys C after treatment in the observation group was significantly superior to that in the control group（P〈0.05）.The improved degree of MAP after treatment in the observation group was significantly superior to that in the control group（P〈0.05）.Conclusions：Routine treatments,comprehensive nursing intervention,and Danshen injection in the treatment of PIH can improve the oxidative stress and inflammatory reaction through regulating the oxygen free radicals in order to reach the goal of reducing the blood pressure.

关 键 词：丹参注射液 妊娠高血压综合征 氧化应激 炎性因子 

分 类 号：R714.252[医药卫生—妇产科学]