皮肌炎相关的肺间质病变经激素联合免疫抑制剂治疗后肺功能变化  

The Changes of Lung Function of Patients Dermatomyositis Associated Interstitial Lung Disease by Hormone Combined with Immunosuppressive Therapy

作　　者：梁志强[1] 姜凤云[1] 赵蕾[1] 王雪燕[1] 常晓华[1] 刘艳伶 王亚婷[1] 

机构地区：[1]承德医学院附属医院风湿免疫科,河北承德067000

出　　处：《河北医学》2016年第10期1600-1602,共3页Hebei Medicine

基　　金：河北省承德市科学技术研究与发展计划项目;(编号:20158001)

摘　　要：目的:探讨皮肌炎相关肺间质病变采用激素联合免疫抑制剂治疗后的肺功能变化效果。方法:入选我院2012年1月至2016年1月收治的皮肌炎患者40例,回顾性分析40例患者的临床资料,患者均给予激素联合免疫抑制剂环磷酰胺治疗,观察其治疗前后血清肌酸激酶水平和肺功能变化。结果:40例患者治疗后,其血清肌酸激酶水平有所改善,患者治疗后的血清肌酸激酶(CK)的变化值优于治疗前,差异具有统计学意义(P<0.01);患者治疗后的肺功能指标水平优于治疗前,差异具有统计学意义(P<0.05)。结论:皮肌炎相关的肺间质病变采用激素联合免疫抑制剂治疗,有效的改善了患者的肺功能变化,减少了患者的临床痛苦,提高了临床治疗效果,预后良好,值得临床推广应用。Objective：To investigate the lung function changes of hormone combined with immunosup-pressive in the treatment of dermatomyositis associated interstitial lung disease.Methods：40 patients with der-matomyositis in our hospital from January 2012 to January 2016 were selected,and retrospectively analyzed the clinical data of 40 patients,all patients were treated with hormone and immunosuppressive therapy,the changes of serum creatine kinase level and pulmonary function were observed before and after treatment.Results：After treatment, the levels of 40 cases of patients serum creatine kinase was improved, serum creatine kinase （ CK） values was significantly higher than those before, the difference was statistically significant （ P 〈 0.01）;after treatment,patients with pulmonary function level was better than before treatment, the difference was statisti-cally significant （P〈0.05）.Conclusion：Dermatomyositis with interstitial lung disease with hormone and immu-nosuppressive therapy can effectively improve the pulmonary function, reduce the pain of patients, improve the therapeutic effect, the prognosis is good, it is worthy of clinical application.

关 键 词：皮肌炎 肺间质病变 糖皮质激素 免疫抑制剂 

分 类 号：R593.26[医药卫生—内科学]