山东产忍冬藤中1个新有机酸化合物  

A new organic acid from Lonicerae Japonicae Caulis produced in Shandong

作　　者：贾献慧[1] 唐文照[1] 闫慧娇 李佳[3] 张永清[3] 

机构地区：[1]山东省医学科学院药物研究所山东省罕少见病重点实验室,山东济南250062 [2]山东省分析测试中心,山东济南250014 [3]山东中医药大学,山东济南250355

出　　处：《中草药》2016年第21期3766-3768,共3页Chinese Traditional and Herbal Drugs

基　　金：国家"十二五"科技支撑计划课题资助项目(2011BAI06B01);山东省医学科学院科技计划项目(2015-23)

摘　　要：目的对山东产忍冬藤Lonicerae Japonicae Caulis进行化学成分研究。方法通过反复硅胶、MCI-gel树脂、Sephadex LH-20等多种柱色谱技术进行化学成分分离纯化,依据化合物理化性质和波谱学数据鉴定其结构。结果从山东产忍冬藤中分离并鉴定了4个化合物,分别为11,14,15-三羟基-12-烯-十八碳酸甲酯(1)、金莲木黄酮(2)、β-胡萝卜苷(3)、马钱素(4)。结论化合物1为一个新化合物,命名为忍冬酸酯,化合物2为首次从忍冬藤中分离得到。Objective To study the chemical constituents ofLonicerae Japonicae Caulis produced in Shandong Province. Methods Compounds were isolated and purified by repeated column chromatographies including silica gel, MCI-gel resin, Sephadex LH-20, and so on. Their structures were elucidated by spectral data, including extensive 1D and 2D NMR techniques. Results Four compounds were obtained and identified as 11,14,15-trihydroxy-12-octadecenoic acid methyl ester （1）, ochnaflavone （2）, β-daucosterol （3）, and loganin （4）. Conclusion Compound 1 is a new organic acid named as loniceric acid ester, and compound 2 is isolated from Lonicerae Japonicae Caulis for the first time.

关 键 词：忍冬藤 忍冬酸酯 金莲木黄酮 β-胡萝卜苷 马钱素 

分 类 号：R284.1[医药卫生—中药学]