抗菌肽对糜烂型OLP患者唾液中真菌的影响  

Antibacterial Peptide Effect on Fungi for Erosion Type OLP Patients Saliva

作　　者：郭岩[1] 张英[1] 

机构地区：[1]中国医科大学附属口腔医院急诊粘膜科,辽宁沈阳110001

出　　处：《微生物学杂志》2016年第5期74-77,共4页Journal of Microbiology

摘　　要：抗菌肽经临床研究,发现具有抗生素不具备的优点,可对糜烂型口腔扁平苔藓(oral lichen planus,OLP)患者唾液中真菌有抑制和杀菌的作用,弥补了抗生素的缺点。通过使用不同浓度、不同种类的抗菌肽,作用于自糜烂型OLP患者口腔唾液标本中提取并经鉴定的菌种,对三种常见菌——白色念珠菌、光滑念珠菌、热带念珠菌进行抑菌试验。结果表明,抗菌肽使用前后的数值比对、菌落生长情况、最小抑菌值有明显变化。发现RISE-AP12对三种常见真菌的抑菌、杀菌效果优于其他的抗菌肽,在临床上有较大应用前景。It was found through clinical studies that antibacterial peptide has the advantages that antibiotics do not have,and could inhibit and kill fungi in saliva of erosion type OLP（ oral lichen planus） patients,and makes up the shortcoming of antibiotics. Inhibition experiment using different concentrations, different kinds of antibacterial peptide,action on strains isolated and identified from oral auto-erosion type OLP patients saliva samples against three common fungi,Candida albicans,smooth candida,tropical candida were carried out. The results showed that the numerical comparison,the colony growth,the minimum bacteriostatic values before and after using antibacterial peptides have changed significantly. It was found that the inhibition and killing effects of RISE-AP12 against three common fungi excelled or outwent other antibacterial peptides,and has fairly wide prospect in clinical application.

关 键 词：口腔糜烂型扁平苔藓 念珠菌 抗菌肽 

分 类 号：Q939.92[生物学—微生物学] R978[医药卫生—药品]