2013年东莞市自然人群麻疹抗体水平监测分析  

Surveillance on the antibody level of measles in natural population in Dongguan City,2013

作　　者：唐萃菲[1] 陈绍丽[1] 张巧利[1] 莫想换[1] 林瑞彬 王莹[1] 

机构地区：[1]东莞市疾病预防控制中心,广东东莞523000

出　　处：《实用预防医学》2016年第12期1444-1447,共4页Practical Preventive Medicine

基　　金：东莞市科技计划项目(20121051504414)

摘　　要：目的 了解东莞市自然人群麻疹抗体水平现状,为制定更科学、可行、有效、经济的麻疹防控措施提供科学依据。 方法 以东莞地区分布为特征分片区,采用多阶段随机抽样方法,按片区随机抽取5个镇（街）15个居委会/行政村,每个居委会/行政村随机抽取0-12月龄每个月龄、1-14岁每个年龄、15岁-、20岁-、25岁-、30岁-、35岁-、40岁-、45岁-等每个年龄段各4人（为保证育龄妇女调查人数,要求≥15岁的各年龄组调查对象男女比例为11）,共抽取2 043人作为本次监测对象;采集每名对象的静脉血分离血清后应用酶联免疫吸附试验法（ELISA）检测麻疹IgG抗体。 结果 本省外市户籍人群麻疹抗体水平（GMC 1 092.38 mIU/ml,阳性率81.53%,保护率53.13%）和外省户籍人群麻疹抗体水平（GMC 985.80 mIU/ml,阳性率73.12%,保护率48.29%）均低于本市户籍麻疹抗体水平（GMC 1 106.79 mIU/ml,阳性率85.09%,保护率54.83%）,其中阳性率和保护率总体比较差异有统计学意义（χ^2阳性率=35.789,P〈0.001;χ^2保护率=6.606,P=0.037）;各年龄组间麻疹抗体水平差异有统计学意义（FGMC=26.388,P〈0.001;χ^2阳性率=905.853,P〈0.001;χ^2保护率=436.861,P〈0.001）;2-8月龄婴儿麻疹抗体水平（GMC 257.74 -613.53 mIU/ml,阳性率10.53%-62.40%,保护率4.39%-23.20%）最低,9-15岁儿童麻疹抗体水平（GMC 879.12-987.97 mIU/ml,阳性率89.57%-94.92%,保护率40.68%-54.78%）也较低,15-35岁育龄妇女麻疹抗体GMC在1 200 mIU/ml左右波动,35岁以上育龄妇女麻疹抗体GMC显著上升,抗体阳性率、抗体保护率变化特征与抗体GMC大致相同。 结论 2014年广东省东莞市内外市户籍人群和外省户籍人群、2-8月龄婴儿、9-15岁儿童、35岁以下育龄期妇女为麻疹抗体水平薄弱群体,加强常规免疫、健康宣教、强化免疫、应急接种等免疫干预可有助于实现麻疹低发阶段有效防控。Objective To investigate the current situation of measles antibody level among natural population in Dongguan City so as to provide scientific evidence for formulating more scientific, feasible, effective and economical measures for measles prevention and control. Methods Based on the regional distribution characteristics of Dongguan, 5 towns/streets and 15 neighborhood committees/administrative villages were selected from different areas using the multi-stage random sampling method. 4 persons were randomly recruited from each month-age group of the infants aged 0-12 months, each year-age group of children aged 1-14 years and each group of 15-, 20-, 25-, 30-, 35-, 40- and 45 years old in each neighborhood committee/administrative village. In order to ensure enough women of childbearing age recruited, the ratio of male to female subjects in each group aged ≥ 15 years was 11. Finally, 2,043 individuals were recruited for monitoring. Venous blood was collected from each subject and serum was separated. Enzyme linked immunosorbent assay （ELISA） was used to detect serum measles IgG antibody. Results The measles antibody levels in the population with household registry of other cities in Guangdong Province （geometric mean concentration （GMC） 1,092.38 mIU/ml, positive rate 81.53% and protection rate 53.13%） and in the population with household registry of other provinces （GMC 985.80 mIU/ml, positive rate 73.12% and protection rate 48.29%） were lower than those of the population with household registry of Dongguan City （GMC 1,106.79 mIU/ml, positive rate 85.09% and protection rate 54.83%）, of which the positive rate（χ^2=35.789, P〈0.001） and protection rate were statistically different （χ^2=6.606, P=0.037）. The measles antibody levels were significantly among various age groups （FGMC=26.388, P〈0.001; χ^2 positive rate=905.853, P〈0.001; χ^2 protection rate=436.861, P〈0.001）.The measles antibody levels of the infants aged 2-8 months （GMC 257.74-613.53 mIU/ml, positive rate 10.

关 键 词：自然人群 麻疹 抗体水平 监测 

分 类 号：R511.1[医药卫生—内科学]