使用甘草酸二铵治疗急性黄疸型病毒性肝炎的效果研究  

Clinical study of acute icteric viral hepatitis treated with Diammonium Glycyrrhizinate

作　　者：陈红梅[1] Chen Hongmei(Department of pharmacy, the Fourth People＇s Hospital of Panzhihua City of Sichuan Province, Panzhihua,Sichuan, 617061)

机构地区：[1]四川省攀枝花市第四人民医院药剂科,四川攀枝花617061

出　　处：《当代医药论丛》2016年第20期15-16,共2页

摘　　要：目的:探讨使用甘草酸二铵治疗急性黄疸型病毒性肝炎的效果。方法:选取近两年我院收治的98例急性黄疸型病毒性肝炎患者作为研究对象。随机将这些患者分为对照组和实验组,每组各49例患者。为对照组患者使用门冬氨酸钾镁注射液进行治疗,为实验组患者使用甘草酸二铵进行治疗。然后比较两组患者治疗的效果、血清总胆红素(TBi L)的水平、丙氨酸转氨酶(ALT)的水平及不良反应的发生情况。结果:经治疗,实验组患者治疗的总好转率、TBi L的水平、ALT的水平均明显优于对照组患者,差异具有统计学意义(P<0.05)。治疗期间,两组患者不良反应的发生率相比,差异无统计学意义(P<0.05)。结论:使用甘草酸二铵治疗急性黄疸型病毒性肝炎的效果显著,可有效地改善患者的临床症状。Objective： evaluation of acute icteric viral hepatitis with clinical efficacy and safety of diammonium glycyrrhizinate treatment. Methods： according to the inclusion criteria from patients with acute icteric viral hepatitis in our hospital were selected 98 cases as the research object, randomly divided the contains 49 cases of control group and the experimental group, the former only accept Potassium Magnesium Aspartate Injection treatment, while the latter is given Diammonium Glycyrrhizinate in the treatment of, after the completion of the treatment period of 3W assess differences in clinical efficacy was compared between the two groups and observe improvement of liver function in patients with status and adverse reaction of the situation. Results： in the experimental group, clinical treatment, the total improvement rate was 95.9%, compared to 77.6% in the control group were significantly higher（P 〈 0.05）, compared two groups of patients with treatment of TBIL, ALT and liver function indexes had no significant difference（P 〉0.05） and treatment groups were compared before and after each index were decreased（P 〈 0.05）, and the experimental group decreased more significantly（P 〈 0.05）; in the control group, the adverse reaction rate was 6.1%, compared to the experimental group of 2.0% were of no statistical significance（P 〈 0.05）. Conclusion： for acute icteric viral hepatitis give diammonium glycyrrhizinate treatment helps in jaundice subsided, associated symptoms, clinical effect significantly, can be recommended as an ideal drug use.

关 键 词：急性黄疸型病毒性肝炎 甘草酸二铵 肝功能 

分 类 号：R512.6[医药卫生—内科学]