基于2-卤甲基-3-喹啉甲酸乙酯的反应研究进展  

Research progress on the reaction of ethyl 2-( halogenmethyl)quinoline-3-carboxylate

作　　者：符鑫博 王东方[1] 赵雅楠[1] 李阳[1] 高文涛[1] FU Xin-bo WANG Dong- fang ZHAO Ya-nan LI Yang GAO Wen-tao(Institute of Superfine Chemicals,Bohai University,Jinzhou 121000,China)

机构地区：[1]渤海大学超精细化学品研究所,辽宁锦州121000

出　　处：《化学研究与应用》2016年第11期1505-1517,共13页Chemical Research and Application

基　　金：国家自然科学基金项目(21476028)资助

摘　　要：喹啉及其衍生物是一类重要的杂环化合物,许多具有生物活性的稠杂环化合物中都含有喹啉骨架。由2-卤甲基-3-喹啉甲酸乙酯合成多环或稠杂环化合物的研究进展还未见文献报道。为更好地了解这方面的研究动态,本文综述了近几年有2-卤甲基-3-喹啉甲酸乙酯参与反应的研究进展,主要涉及了2-氯(溴)甲基-3-喹啉甲酸乙酯与酚、胺、水杨醛和芳香醛等的一系列反应。Quinoline and its derivatives are very important heterocyclic compounds,and many quinoline-containing heterocyclicfused compounds have been found to exhibit potent biological activities.To the best of our knowledge,there is not any review summarizing the literature on the use of ethyl 2-（ halogenmethyl） quinoline-3-carboxylate as the building blocks for synthesis of quinolinebearing polycyclic heterocyclic-fused systems.As such,in order to cover the recent work in this aspect,and provide useful and up-todate data for organic chemists,the present review focuses mainly on the reaction of ethyl 2-（ halogenmethyl） quinoline-3-carboxylate with phenols,amines,salicylaldehydes,aldehydes and so on.

关 键 词：喹啉 卤甲基 稠杂环化合物 合成 研究进展 

分 类 号：O625[理学—有机化学]