胎盘组织缺氧诱导因子-1α和内皮素-1表达对糖尿病妊娠的影响  

Influence of placental hypoxia inducible factor-1α and endothelin-1 in gestational diabetes patients

作　　者：屈莉红[1] 荆鲁宁[1] 

机构地区：[1]山东省海阳市人民医院产科,山东海阳265100

出　　处：《中国现代医学杂志》2016年第20期44-47,共4页China Journal of Modern Medicine

摘　　要：目的探究分析胎盘组织缺氧诱导因子-1α(HIF-1α)和内皮素-1(ET-1)表达对糖尿病妊娠的影响。方法分别选取糖尿病妊娠患者30例(糖尿病妊娠组)、妊娠期糖尿病患者30例(妊娠糖尿病组)以及正常孕妇30例(对照组)。采用免疫组织化学法SP法测定EF-1及HIF-1α蛋白的含量,比较并分析各组检测结果差异及其对糖尿病妊娠结局的影响。结果糖尿病妊娠患者胎盘组织EF-1及HIF-1α蛋白阳性表达率显著高于妊娠糖尿病患者及对照组(P<0.05),糖尿病妊娠患者的产后出血、胎儿生长受限及妊娠高血压等并发症发生率(50.00%)显著高于妊娠糖尿病患者(30.00%)及对照组(10.00%),各组比较差异有统计学意义(P<0.05)。结论胎盘组织EF-1及HIF-1α蛋白表达情况对糖尿病妊娠患者的妊娠结局具有不良影响,EF-1及HIF-1α蛋白阳性表达率越高,妊娠并发症发生率明显增加,胎盘损害越严重。Objective To explore the the influence of placental hypoxia inducible factor 1 alpha （HIF-1α） and endothelin-1 （ET-1） in gestational diabetes. Methods A number of 30 patients diabetes during pregnancy and 30 gestational diabetes patients were selected, and 30 cases of normal pregnant women were selected at the same time as a control group. Immune histochemical method and SP method were used to detect EF-1 and HIF-1α protein content. Differences between groups of test result and its influence on pregnancy outcomes of diabetes were compared and analysis. Results The placental tissue EF-1 and HIF-1α protein positive expression rate in patients with diabetes during pregnancy was significantly higher than that of gestational diabetes mellitus patients and the control group （P 〈 0.05）. Patients with diabetes during pregnancy had higher rate of postpartum hemorrhage, fetal growth restriction and higher incidence of complications （P 〈 0.05）. Conclusions The expressions of EF-1 and HIF-1α protein in placental tissue have adverse effects on patients with diabetes during pregnancy.

关 键 词：胎盘组织 HIF-α ET-1 糖尿病妊娠 

分 类 号：R714.256[医药卫生—妇产科学]