磷酸神经鞘氨醇在胃癌中的表达及临床意义  

Expression and clinical significance of sphingosine 1-phosphate in human gastric cancer

作　　者：陈小琴[1] 梁鑫[2] 李喆倩[1] 徐嘉昌[1] 谢国锦[1] 陈红兵[1] 陈云[3] 

机构地区：[1]南京医科大学附属儿童医院检验科,江苏省210008 [2]江苏省中医院检验科 [3]南京医科大学免疫教研室

出　　处：《江苏医药》2016年第21期2324-2327,F0003,共5页Jiangsu Medical Journal

摘　　要：目的探讨磷酸神经鞘氨醇(S1P)在胃癌组织中的表达及其临床意义。方法采用实时荧光定量PCR和免疫组织化学染色检测60例胃癌组织及其癌旁正常胃黏膜组织中S1P和S1P受体1(S1PR1)的表达,分析血清S1P表达与胃癌患者预后的关系。结果 S1P和S1PR1在胃癌组织中的表达均高于癌旁正常胃黏膜组织(P<0.01)。S1P表达与S1PR1和IL-6表达均呈正相关(r=0.304和0.241,P<0.01)。胃癌患者血清S1P的表达与术后累积生存率呈负相关(HR=2.246,P<0.01)。结论 S1P在胃癌组织中高表达,在胃癌进展中发挥重要作用,有望成为胃癌预后判断和治疗的新靶点。Objective To investigate the expression and clinical significance of sphingosine 1-phosphate（SIP） in human gastric cancer. Methods The expressions of SIP and its receptor S1PR1 were detected by real-time fluorescent quantitative PCR and immunohistochemistry in 60 cases of gastric cancer tissues and its tumor-adjacent normal tissues. And the relationship between serum S1P expression and prognosis of the patients with gastric cancer was analyzed. Results The expressions of SIP and S1PR1 in gastric cancer tissues were higher than those in tumor-adjacent normal tissues （P〈0. 01）. SIP expression was positively correlated with S1PR1 and IL-6 expressions（r=0. 304 and 0. 241 ,P〈0. 01）. Serum SIP expression was negatively relevant to the cumulative survival rate after operation in the patients with gastric cancer （HR = 2. 246, P〈0. 01 ）. Conclusion SIP is highly expressed in gastric cancer tissues, which plays an important role in the development of gastric cancer and may hopefully serve as a new target for theraoy and an indicator for the orediction of prognosis.

关 键 词：磷酸神经鞘氨醇 胃癌 

分 类 号：R392[医药卫生—免疫学]