氨溴索辅助支气管肺泡灌洗术对颅脑外伤患者行气管切开后相关指标的影响  

Effects of Ambroxol Assisted with BAL on Related Indicators of Patients with Tracheotomy for Traumatic Brain Injury

作　　者：吴颖[1] 刘淑红[1] 刘亚晶[1] 崔朝勃[1] 赵媛媛[1] 

机构地区：[1]衡水市哈励逊国际和平医院重症医学科,河北衡水053000

出　　处：《中国药房》2016年第33期4644-4646,共3页China Pharmacy

基　　金：衡水市科学技术研究与发展计划项目(No.14019A)

摘　　要：目的:探讨氨溴索辅助支气管肺泡灌洗(BAL)术对颅脑外伤患者行气管切开后相关指标的影响。方法:90例颅脑外伤行气管切开患者随机分为对照组(45例)和观察组(45例)。两组患者均行止血、吸痰、气管雾化、持续吸氧及抗菌药物预防应用等常规治疗。在此基础上,对照组患者行BAL术;观察组患者于BAL术后加用盐酸氨溴索注射液30 mg,加入0.9%氯化钠注射液100 ml中,静脉滴注,每日3次。两组疗程均为7 d。观察两组患者术后肺部感染发生情况,术后1、3、5、7 d的白细胞计数和多形核细胞计数。结果:观察组患者铜绿假单胞菌、鲍曼不动杆菌、肺炎克雷伯菌和金黄色葡萄球菌感染发生率均显著低于对照组,差异均有统计学意义(P<0.05)。术后,两组患者白细胞计数、多形核细胞计数均显著低于同组术前,随时间延长逐渐降低,且观察组低于对照组,差异均有统计学意义(P<0.05)。结论:在常规治疗的基础上,氨溴索辅助BAL术可有效降低颅脑外伤患者行气管切开后的肺部感染发生率及炎症水平。OBJECTIVE： To investigate the effects of ambroxol assisted with BAL on the related indicators of patients with tra- cheotomy for traumatic brain injury. METHODS： 90 patients with tracheotomy for traumatic brain injury were randomly divided in- to control group （45 cases） and observation group （45 cases）. All patients received hemostasis, sputum suction, airway atomiza- tion, continuous oxygen uptake, preventive use of antibiotics and other conventional treatment. Based on it, control group was tak- en BAL; observation group was additionally given Ambroxol hydrochloride injection 30 mg after BAL, adding into 0.9% Sodium chloride injection 100 ml, intravenous infusion, 3 times a day. The 2 groups were treated for 7 d. The incidence of postoperative lung infection, the numbers of white blood cells and polymorphonuclear cells in 2 groups after 1, 3, 5, 7 d in 2 groups were ob- served. RESULTS： The infection incidences of pseudomonas aeruginosa, acinetobacter banmannii, klebsiella pneumoniae and staph- ylococcus aureus in observation group were significantly lower than control group, with statistical significance （P〈0.05）. After op- eration, the numbers of white blood cells and polymorphonuclear cells in 2 groups were significantly lower than before, gradually decreased with time, and observation group was lower than control group, with statistical significances （P〈0.05）. CONCLU- SIONS： Based on conventional treatment, Ambroxol assisted with BAL can effectively reduce the incidence of lung infection and in- flammation levels for patients with tracheotomy for traumatic brain injury.

关 键 词：氨溴索 支气管肺泡灌洗术 颅脑外伤 气管切开 肺部感染 

分 类 号：R651.11[医药卫生—外科学]