琥珀酸索利那新片治疗膀胱过度活动症的效果分析  

Effect of Treatment of Overactive Bladder with Succinate

作　　者：马江[1] 李小顺[1] 董维平[1] 张璞暹[1] 李刚[1] 

机构地区：[1]武警陕西总队医院泌尿外科,陕西西安710054

出　　处：《现代生物医学进展》2016年第31期6100-6102,共3页Progress in Modern Biomedicine

基　　金：陕西省卫生厅医学联合基金项目(2015211C209)

摘　　要：目的:观察琥珀酸索利那新片治疗膀胱过度活动症的临床效果。方法:回顾性分析我科收治的膀胱过度活动症患者共90例,所有患者均符合由中华医学会泌尿外科分会尿控学组制定的《膀胱过度活动症临床指导原则》。其中43例患者采用酒石酸托特罗定片治疗并设为对照组,47例患者采用琥珀酸索利那新片治疗并设为观察组,对比两组患者用药前后排尿症状和尿动力学参数变化、膀胱过度活动症症状评分表(OABSS评分)和前列腺症状评分(IPSS评分)变化以及不良反应发生率对比情况。结果:观察组患者用药后平均24 h尿急次数、平均24 h排尿次数均明显低于对照组,最大尿流率(Qmax)、初始尿意容量(FDV)、最大膀胱压容量(MCBC)均明显高于对照组,两组患者以上指标相比较,差异均有显著性(P<0.05);两组患者用药后OABSS评分和IPSS评分均有所下降,但是两组相比,差异不具有显著性(P>0.05);3两组患者用药后均有不同程度的不良反应,其中口干症状患者比例具有差异性(P<0.05)。结论:琥珀酸索利那新片治疗膀胱过度活动症疗效确切,安全性高。Objective： To observe the effect of succinate treatment on overactive bladder. Methods： A total of 90 overactive bladder patients were included in this study. All patients were in line with Guiding Principles on overactive bladder established by continence study group of urology branch of the Chinese Medical Association. 43 patients were treated with tolterodine treatment and set as the control group. 47 patients were treated with succinate solifenacin treatment and set as observation group. Compare the micturition symptoms and urodynamic parameters before and after treatment, overactive bladder symptom Scale（OABSS rates） and prostate symptom score（IPSS score） changes and incidence of adverse reactions between two groups. Results： After treatment, patients in observation group had less urgency times per 24 h, less frequency of urination per 24 h than the control group. The maximum flow rate（Qmax）, the initial capacity to urinate（FDV）, maximum bladder pressure capacity（MCBC） were significantly higher in observation group than the control group. The differences were significant in the above mentioned indicators（P 〈0.05）. IPSS scores and OABSS score decreased after treatment in two groups, but there were no significant differences between two groups（P〉 0.05）. 3 Patients in both groups had different degrees of adverse reactions after treatment. Of them, the proportion of patients with symptoms of dry mouth had differences between two groups（P〈0.05）. Conclusion： The new succinate solifenacin treatment for overactive bladder is effective and safe, and worthy of further promotion and application.

关 键 词：琥珀酸索利那新片 膀胱过度活动症 排尿症状 尿动力学参数 

分 类 号：R694[医药卫生—泌尿科学]