PCOS患者外周血白细胞计数变化的临床意义  

Clinical Significance of Changes of Peripheral Leukocytes Count in Patients with PCOS

作　　者：王文娟[1] 吴海波[1] 杨琴[1] 高敏[1] 刘洋[1] 

机构地区：[1]海军总医院妇产科,北京100048

出　　处：《现代生物医学进展》2016年第31期6118-6120,共3页Progress in Modern Biomedicine

摘　　要：目的：探讨多囊卵巢综合征（PCOS）患者外周血白细胞计数和血脂代谢变化的临床意义。方法：随机抽取2012年1月~2014年1月期间来院就诊未经药物治疗的PCOS患者48例作为研究对象,将体重指数（BMI）≥23的患者26例作为PCOS超重组,将BMI〈23的22例患者作为PCOS体重正常组,选择同期来院就诊的非PCOS妇女20例作为对照组,所有患者均于月经期空腹静脉抽血3~4m L,检测患者的血浆C反应蛋白（CRP）、血常规及血脂代谢指标。结果：PCOS超重组的甘油三酯（TG）、低密度脂蛋白（LDL-C）、载脂蛋白B（Apo-B）、外周白细胞总数、淋巴细胞、中性粒细胞、单核细胞、嗜酸性细胞、CRP指标均较对照组、PCOS体重正常组高,而高密度脂蛋白（HDL-C）、载脂蛋白A（Apo-A）水平较对照组、PCOS体重正常组低,差异均有统计学意义（P〈0.05）;PCOS体重正常组淋巴细胞、CRP指标较对照组高,差异均有统计学意义（P〈0.05）。结论：慢性炎症是PCOS的主要病理表现,其中体重超重的PCOS患者主要表现为血脂代谢异常及白细胞升高,而体重正常的PCOS患者主要表现为淋巴细胞升高。Objective： To explore the clinical significance of changes of lipid metabolism and peripheral leukocytes count in patients with polycystic ovary syndrome（PCOS）. Methods： 48 PCOS patients who were treated in our hospital without drug treatment from Feb 2013 to Feb 2014 were randomly chosen and divided into overweight PCOS group（n=26, BMI ≥23） and normal weight PCOS group（n=22, BMI〈23）. 20 cases without PCOS in the same period were selected as control group. 3~4 mL fasting venous blood were exsanguinated from all patients in the menstrual period. Plasma C-reactive protein（CRP）, blood routine and blood lipid metabolism indexes were detected. Results： Compared with control group and normal weight PCOS group, the levels of triglyceride（TG）, low density lipoprotein（LDL-C）, apolipoprotein B（Apo-B）, the total number of peripheral leukocytes, lymphocytes, neutrophils, monocytes,eosinophils and CRP in overweight PCOS group were higher, while the levels of high density lipoprotein（HDL-C） and apolipoprotein A（Apo-A） were lower, and the differences were statistically significant（P〈0.05）. The levels of lymphocytes and CRP in normal weight PCOS group were higher than the control group, and the differences were statistically significant（P〈0.05）. Conclusion： Chronic inflammation is the main pathological manifestations of PCOS, among which the overweight patients with abnormal lipid metabolism and increasing leukocytosis, while the normal-weight patients with increasing lymphocytes.

关 键 词：多囊卵巢综合征 白细胞 血脂 炎症 

分 类 号：R711[医药卫生—妇产科学]