高通量血液透析对慢性肾衰竭尿毒症患者TLC及免疫球蛋白水平的影响  

Effects of High Flux Hemodialysis on Levels of TLC and Immunoglobulin of Patients with Chronic Renal Failure and Uremia

作　　者：聂丽敏 刘娜[1] 许静[1] 薛兰芬[1] 张国欣[2] 闫康[3] 

机构地区：[1]石家庄市第一医院肾内科,河北石家庄050011 [2]河北医科大学附属人民医院肾内科,河北石家庄050011 [3]石家庄市第三医院心功能室,河北石家庄050011

出　　处：《现代生物医学进展》2016年第31期6141-6143,6168,共4页Progress in Modern Biomedicine

基　　金：河北省科学技术研究与发展计划项目(12277755)

摘　　要：目的:探究高通量血液透析对慢性肾衰竭尿毒症患者TLC及免疫球蛋白水平的影响。方法:选取我院收治的慢性肾衰竭尿毒症患者100例,随机分为实验组和对照组。对照组采用常规血液透析治疗,实验组采用高通量血液透析治疗。观察并比较两组患者治疗前后TLC及免疫球蛋白水平的变化情况以及临床疗效。结果:实验组治疗有效率(96.0%)高于对照组(86.0%),差异有统计学意义(P<0.05);与治疗前相比,两组患者治疗后血肌酐水平下降,IgA,IgM及IgG水平升高,肺功能TLC水平升高,差异具有统计学意义(P<0.05);与对照组相比,实验组患者治疗后血肌酐水平较低,IgA,IgM及IgG水平较高,肺功能TLC水平较高,差异具有统计学意义(P<0.05)。结论:高通量血液透析治疗能够改善慢性肾衰竭尿毒症患者的肺功能,增强免疫功能。Objective： To investigate the effects of high flux hemodialysis on the levels of TLC and immunoglobulin of patients with chronic renal failure uremia. Methods： 100 patients with chronic renal failure and uremia who were treated in our hospital from December 2012 to December 2015 were collected and randomly divided into the experiment group and control group with 50 cases in each group. The patients in the control group were treated with regular hemodialysis, while the patients in the experiment group were treated with high flux hemodialysis. Then the levels of TLC and immunoglobulin and the clinical efficacy of the two groups were observed and compared before and after the treatment. Results： The clinical effective rate of the experiment group was 96.0%, which was higher than86.0% in the control group, and the difference was statistically significant（P〈0.05）; Compared with before treatment, the serum levels of creatinine in the two groups after treatment decreased, while the levels of Ig A, Ig M and Ig G increased, and the lung function TLC increased, and the differences were statistically significant（P〈0.05）. Compared with control group after the treatment, the serum levels of creatinine in the experiment group was lower, and the levels of Ig A, Ig M and Ig G were higher, and TLC lung function was higher, and the differences were statistically significant（P〈0.05）. Conclusion： High flux hemodialysis therapy is better than hemodialysis treatment,which can improve the lung function, enhance the immune function, and improve the clinical efficacy.

关 键 词：慢性肾衰竭尿毒症 高通量血液透析 TLC 免疫球蛋白 

分 类 号：R692[医药卫生—泌尿科学]