Science:肠道病原菌依赖机体修复组织的免疫反应茁壮成长  

出　　处：《现代生物医学进展》2016年第31期I0003-I0003,共1页Progress in Modern Biomedicine

摘　　要：为何一些食源性细菌让我们生病？在一项新的研究中，来自美国加州大学戴维斯分校和德州大学西南医学中心的研究人员发现肠道中的病原菌导致伤害的原因在于这些细菌受益于旨在修复它们起初导致的肠道内壁损伤的免疫系统反应。相关研究结果发表在Science期刊上。论文通信作者、加州大学戴维斯分校医学院医学微生物学与免疫学教授Andreas B？umler说。”这一发现是非常重要的。这是因为它解释了一些肠道病原菌能够操纵哺乳动物细胞来获得它们需要吸入的氧气。它也为开发靶向肠道内壁代谢的策略来阻止有害细菌在肠道中增殖提供新的认识。其中滥用抗生素会恶化有害细菌在肠道中增殖。”Citrobacter rodentium uses a type III secretion system (T3SS) to induce colonic crypt hyperplasia in mice, thereby gaining an edge during its competition with the gut microbiota through an unknown mechanism. Here, we show that by triggering colonic crypt hyperplasia, the C. rodentium T3SS induced an excessive expansion of undifferentiated Ki67-positive epithelial cells, which increased oxygenation of the mucosal surface and drove an aerobic C. rodentium expansion in the colon. Treatment of mice with the γ-secretase inhibitor dibenzazepine to diminish Notch-driven colonic crypt hyperplasia curtailed the fitness advantage conferred by aerobic respiration during C. rodentium infection. We conclude that C. rodentium uses its T3SS to induce histopathological lesions that generate an intestinal microenvironment in which growth of the pathogen is fueled by aerobic respiration.

关 键 词：肠道病原菌 免疫反应 修复 美国加州大学 医学微生物学 有害细菌 组织 机体 

分 类 号：S858.93[农业科学—临床兽医学]