成纤维细胞生长因子23(FGF23)在终末期肾病患者继发性甲状旁腺功能亢进中的作用  被引量:4

Mechanism of Fibrillation Growth Factor 23 (FGF23) in Secondary Hyperparathyroidism for Patients with End-stage Renal Disease

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作  者:王妍妮[1] 杨小娟[1] 刘延[1] 安智[1] 解建国[2] 

机构地区:[1]延安大学附属医院肾内科,陕西延安716000 [2]延安大学附属医院神经内科,陕西延安716000

出  处:《现代生物医学进展》2016年第32期6336-6338,6289,共4页Progress in Modern Biomedicine

基  金:陕西省自然科学基金项目(2008011078-1)

摘  要:目的:探究成纤维细胞生长因子23(FGF23)在终末期肾病患者继发性甲状旁腺功能亢进中的作用机制。方法:选取我院2013年2月-2015年5月期间收治的58例终末期肾病进入血液透析的患者,所有患者均经甲状旁腺CT增强扫描,无增生及结节。按照i PTH值将其分为两组,i PTH>300 pg/m L为观察组,150 pg/m L≤i PHT≤300 pg/m L为对照组,每组29例。患者均予碳酸钙以及活性维生素D3进行治疗。对患者钙、磷、白蛋白、血脂以及FGF23、i PTH、1,25(OH)_2D_3进行检验。结果:治疗后观察组患者FGF23及i PTH均高于对照组,差异具有统计学意义(P<0.05)。观察组血尿素氮、血肌酐与透析前相比明显下降,对照组血尿素氮、血肌酐与透析前相比明显下降,差异有统计学意义(P<0.01);1,25(OH)_2D_3以及血白蛋白水平是影响Log FGF23的独立影响因素。结论:FGF23在终末期肾病患者继发性甲状旁腺功能亢进发病中发生作用,可作用临床诊断依据。Objective: To explore the role of fibroblast growth factor 23(FGF23) in patients with end-stage renal disease.Methods: 58 cases with end stage renal disease who were treated in our hospital from February 2013 to May 2015 were selected and according to the i PTH values, the patients were divided into two groups: i PTH 〉 300 pg / m L as the observation group, 150 pg/m L ≤i PHT≤300 pg/m L as the control group, with 29 patients in each group. Then the calcium, phosphorus, albumin, blood lipids, and levels of FGF23, i PTH, 1,25(OH)2D3in the two groups were observed and compared. Results: The levels of FGF23 and i PTH in the observation group were significantly higher than those of the control group, and the differences were statistically significant(P〈0.05).Compared with the control group, the blood urea nitrogen, creatinine and dialysis in the observation group significantly decreased, and the difference was statistically significant(P〈 0.01); The FGF23 and i PTH decreased in the two groups, and the difference was statistically significant(P 〈 0.01). 1,25(OH)2D3and serum albumin level were the independent influencing factors of FGF23 Log.Conclusion: FGF23 plays a role in the pathogenesis of secondary parathyroid function in patients with end-stage renal disease

关 键 词:成纤维细胞生长因子23 终末期肾病 继发性甲状旁腺功能亢进 

分 类 号:R692.6[医药卫生—泌尿科学]

 

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