源于喉上神经外支的甲状腺神经对甲状腺分泌功能的影响  

Influence of thyroid nerve originated from ELN on thyroid hormone secretion function

作　　者：张江涛[1,2] 胡勇 冉建华[2] 孙善全[2] 

机构地区：[1]遵义医药高等专科学校人体解剖教研室,563002 [2]重庆医科大学神经科学研究所,400016 [3]播州区公安局刑侦大队,563100

出　　处：《重庆医学》2016年第32期4484-4486,共3页Chongqing medicine

基　　金：四川省教委基金项目(川科教1992-51号);重庆市科委中青年科技专家基金(92-3485)

摘　　要：目的探讨源于喉上神经外支(ELN)的甲状腺神经对甲状腺分泌功能的影响。方法随机将21只中华田园犬,抽取3只作为对照组,剩余18只按照手术时间分组,即术后第5、7、9天(分别为A、B、C组),每组各6只,再将其分为假手术组和实验组两个亚组(每亚组各3只)。术前采集各组动物血液样本,麻醉后将假手术组的甲状腺支分离,随即将伤口缝合;于实验组,分离并切断狗的甲状腺支并缝合。在术后的第5、7、9天,分别采集各组狗的血液样本和甲状腺。检测各组血液样本的促甲状腺激素(TSH)和甲状腺素(T4)水平,并将甲状腺作组织学切片检查,然后进行各组比较。结果正常甲状腺滤泡由单层立方形上皮或单层扁平形上皮细胞组成,滤泡内存在胶状质。实验A组可见甲状腺滤泡大小不等,部分萎缩,腺泡内胶状质减少;B组和C组发现甲状腺滤泡进一步萎缩,排列紊乱,滤泡内胶状质也进一步减少。同时实验A、B、C组生物化学检测发现TSH水平随着时间的延长而增加,但T4水平却随着时间的延长而显著减少。结论 ELN支配甲状腺的分支可能通过调节甲状腺血管的舒缩,控制甲状腺素的分泌。Objective To investigate the influence of the thyroid nerve originated from external laryngeal nerve（ELN） on thyroid hormone secretion function. Methods Three dogs were randomly extracted from 21 Chinese field dogs and the remaining 18 cases were divided into the group A, B and C according to the operation time,i, e. ,on postoperative 5,7,9 d,6 cases m each group. Then each group was re-divided into the sham operation subgroup and experimental subgroup. The blood samples were collected be- fore operation. The thyroid nerve branch in the sham operation group was separated after anesthesia and the wound was sutured; whereas the experimental group was performed the thyroid nerve branch separation, cutting off and suture. The blood samples and thyroid in each group were collected on postoperative 5,7,9 d. The levels of thyrotropic hormone（TSH） and T4 were detected. The thyroid was performed the histological section examination. Results The normal thyroid gland follicles consisted of simple cuboidal or simple flattened epithelial cells. The colloid materials existed within the follicles. The group A showed that follicles were unequal in size with partial atrophy and the colloid material in follicles was decreased; the group B and C found that thyroid follicles were further atrophied with arrange in disorder and the colloid material in follicles was further decreased. At the same time. the biochemi- cal detection in the group A,B and C found that the TSH level was increased with time extending,while the T4 level was signifi- cantly decreased. Conclusion ELN governing the thyroid nerve branch controls the thyroid hormones secrenon possibly by regula- ting the vasomotion of thyroid artery.

关 键 词：喉上神经外支 甲状腺 胶状质 促甲状腺激素 甲状腺素 

分 类 号：R581[医药卫生—内分泌]