银黄消痤胶囊对兔耳痤疮模型抗角化作用的实验研究  

Experimental study on Chinese medicine Yinhuang capsule of eliminating acne in rabbit ear

作　　者：连莉阳[1] 王军[2] 李治牢[1] 王晓莉[1] 

机构地区：[1]陕西中医药大学附属医院皮肤科,咸阳712000 [2]陕西中医药大学附属医院病理科,咸阳712000

出　　处：《陕西中医》2016年第12期1684-1685,共2页Shaanxi Journal of Traditional Chinese Medicine

基　　金：陕西中医药大学青年基金项目(2015QN15);陕西中医药大学附属医院院内制剂课题(2014-45)

摘　　要：目的:探讨银黄消痤胶囊治疗寻常痤疮的作用机理。方法:将60只雄兔随机分为空白组、模型组、银黄大、银黄中、银黄小及阳性对照组,每组各10只,后5组建立兔耳痤疮模型,造模成功后,前两组用纯净水灌胃,后四组分别用银黄消痤胶囊大、中、小剂量及珍珠暗疮片混悬液灌胃。2周后取兔耳痤疮标本作组织学切片,光镜下观察皮损病理变化。结果:银黄大剂量组和阳性对照组均可明显改善皮损角化过程,与模型组比较有显著性差异,且银黄大剂量组疗效优于对照组。结论:银黄消痤胶囊治疗寻常痤疮机理是减轻皮损角化及真皮炎症。Objective：To observe the anti-comedone effect of Yinhuang capsule of eliminating acne .Meth-ods ：Using the coal tar daubing to the area nearby the opening of male rabbit ear canal daily for two weeks .Then they were randomly divided into Yinhuang high dose ,middle dose ,low dose ,and model groups ,control groups ,fedding with the drug solution ,and water for two weeks .Results ：Observing the pathological changes on the rabbit ear , they were similar to the findings of acne in human beings under optic microscope .The high dose and control group were markedly alleviated symptoms after 4 weeks ,but there is a little change in the other groups .Conclusions ：Yinhuang capsule of eliminating acne could reduce the hair follicles keratinous plug and dermal inflammation .

关 键 词：寻常痤疮 @银黄消痤胶囊 动物实验 

分 类 号：R758.73[医药卫生—皮肤病学与性病学]