畲族人群双侧上肢收缩压差异与动脉硬化研究  

Study on Inter Arm Difference of Systolic Blood Pressure of Bilateral Upper Limbs and Arteriosclerosis in the She Nationality

作　　者：刘欢[1] 洪永强[2] 吴秀琴[2] 张晓滨[2] 黄孟华[2] 王宏宇[1] Liu Huan Hong Yong-qiang Wu Xiu-qin et al(Peking University Shougang Hospital,Beijing 100144,China Mindong Hospital Affliated to Fujian Medical University,Ningde 355000,China)

机构地区：[1]北京大学首钢医院血管医学科,北京100144 [2]福建医科大学附属闽东医院超声医学科,宁德355000

出　　处：《中国医药导刊》2016年第11期1081-1082,1084,共3页Chinese Journal of Medicinal Guide

基　　金：卫生部十年百项计划项目(编号:2004-10-01);项目名称:血管病变早期检测技术推广;2014年福建省医学创新课题(编号:2014-CXB-25);项目名称:中国福建畲族自然人群血管功能评价及其危险因素分析;2015年北京市石景山区科技计划项目(编号:无);项目名称:石景山区居民血管事件早期检测系统的建立及其预测价值研究

摘　　要：目的:探讨中国福建畲族自然人群双侧上肢收缩压差异(IAD)与动脉硬化的关系。方法:2009年入选畲族自然人群418例,其双侧上肢血压能够通过动脉硬化自动检测装置(VS-1000)同时记录得到。IAD为左侧与右侧收缩压差值的绝对值,分别按IAD不同水平分成两组,即IAD10组(IAD<10mm Hg和IAD≥10mm Hg),IAD15组(IAD<15mm Hg和IAD≥15mm Hg组)。结果:在IAD增高组(IAD≥10mm Hg组或IAD≥15mm Hg),其年龄、男性比例、颈-股动脉脉搏波传导速度(CF-PWV)水平显著高于IAD正常组(IAD<10mm Hg或IAD<15mm Hg组),双侧踝臂指数(ABI)水平显著低于IAD正常组。将IAD作为连续性变量进行分析,提示年龄、超敏C反应蛋白(hs-CRP)、白细胞计数(WBC)、CF-PWV与IAD呈显著正相关性(r=0.125、0.155、0.104、0.164,P<0.05),双侧ABI与IAD呈显著负相关性(r=-0.297[左]、-0.309[右],均P<0.01)。进一步控制了年龄和性别之后,hs-CRP(r=0.150,P=0.021)、CF-PWV(r=0.198,P=0.002)、双侧ABI(r左=-0.411,r右=-0.350,均P=0.000)仍与IAD显著相关。结论:在中国福建畲族自然人群中,IAD增高者的动脉硬化水平显著高于IAD正常者,ABI显著低于IAD正常者。此外,ABI与IAD显著负相关,CF-PWV、WBC、hs-CRP与IAD显著正相关。Objective： To investigate the relationship between bilateral upper extremity difference in systolic blood pressure and atherosclerosis in She Nationality natural population of Fujian in China. Methods： 418 cases of the She Nationality natural population in 2009 were enrolled into the study. The bilateral upper extremity blood pressure were recorded simultaneously by arteriosclerosis device（VS-1000） automatically. Inter arm difference（IAD） was computed as the absolute value of left arm blood pressure minus right arm blood pressure. According to the different levels of IAD, we divided all subjects into two groups, namely group IAD10（IAD10mm Hg and IAD≥10mm Hg）, IAD15 group（IAD15mm Hg and IAD≥15mm Hg）. Results： In IAD increased group（IAD≥10mm Hg or IAD≥15mm Hg）, age, male proportion, carotid femoral pulse wave velocity（CF-PWV） were significantly higher than that in normal IAD group（IAD〈10mm Hg or IAD〈15mm Hg）, bilateral ankle brachial index（ABI） was significantly lower than that of normal IAD group. Analysis using IAD as a continuous variable showed that age, high sensitive C reactive protein（hs-CRP）, white blood cell count（WBC）, and CF-PWV were significantly positive correlation with IAD（r=0.125, 0.155, 0.104, 0.164, P〈0.05）, there was a significant negative correlation between IAD and bilateral ABI（r=-0.297[left] and-0.309[right]. P〈0.01）. After controlling for age and sex, hs-CRP（r=0.150, P=0.021）, CF-PWV（r=0.198, P=0.002）, bilateral ABI（r left =-0.411, r right =-0.350, P=0.000, P=0.021） were still significantly correlated with IAD. Conclusion： In natural population of Fujian She Nationality in China, the level of arteriosclerosis was significantly higher and ABI was lower in higher IAD group than in normal IAD group. In addition, ABI and IAD were significantly negatively correlated, CF-PWV, WBC, hs-CRP and IAD were significantly positively correlated.

关 键 词：畲族 双侧上肢血压差异 动脉硬化 

分 类 号：R543.5[医药卫生—心血管疾病]