拉米夫定对肝硬化患者脾切除术后临床相关指标的影响  

Effect of lamivudine on clinical relevant indicators of patients with liver cirrhosis after splenectomy

作　　者：李振毅[1] 

机构地区：[1]宁夏石嘴山市第一人民医院,宁夏石嘴山753200

出　　处：《中国生化药物杂志》2016年第9期52-53,共2页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探究拉米夫定对肝硬化患者脾切除术后临床相关指标的影响。方法选取宁夏石嘴山市第一人民医院2002年7月-2012年7月收治的肝硬化行脾切除术患者30例,随机分成观察组和对照组2组,每组各15例。对照组患者单纯行脾切除术,观察组患者行脾切除术后,口服拉米夫定100 mg/次,1次/d,服用1年以上。观察2组治疗前与治疗后的HBV-DNA定量、肝脏功能、凝血酶原时间变化,同时注意并发症情况。结果观察组乙肝病毒基因（HBV-DNA）定量检查结果中患者的转阴率为33.33%,较对照组高（P〈0.05）;观察组较对照组总胆红素（T-BIL）、丙氨酸氨基转移酶（ALT）明显减少（P〈0.05）、白蛋白（ALB）升高显著（P〈0.05）,凝血酶原时间（PT）也明显减少（P〈0.05）。观察组出现腹水、消化道出血2例,对照组出现腹水、激发感染等并发症8例,2组比较差异有统计学意义（P〈0.05）,但均无严重不良反应。结论肝硬化患者行脾切除术后联合拉米夫定治疗,能有效改善患者的临床相关指标,降低不良反应。Objective To explore the effect of lamivudine on clinical relevant indicators of patients with liver cirrhosis after splenectomy. Methods30 cases of patients with liver cirrhosis after splenectomy from July 2002 to July 2012 were selected in Ningxia Shizuishan First People＇s Hospital,and randomly divided into control group and observation group,each had 15 cases. Control group underwent splenectomy only,the observation group was given oral lamivudine,100 mg/times,one times/d,taking more than one years after splenectomy. The changes of HBV-DNA ration,liver function,prothrombin time and other indexes of the two groups before and after treatment were observed in the treatment process,and the complications after treatment were also observed. Results The hepatitis B virus gene（HBV-DNA） quantitative examination results of patients in observation group with negative rate was 33. 33%,the control group had no change; total bilirubin（T-BIL）,alanine aminotransferase（ALT） in observation group decreased significantly than control group（P〈0. 05）,albumin（ALB） increased significantly（P〈0. 05）,prothrombin time（PT） also decreased significantly（P〈0. 05）. There were two cases of complications such as ascites,gastrointestinal bleeding in the observation group,which eight cases in control group,the difference was significant. Conclusion The combination of lamivudine treatment on patients with cirrhosis after splenectomy improves the life quality of patients,safely and effectively promoting the rehabilitation of patients.

关 键 词：肝硬化 脾切除术 拉米夫定 肝脏功能 

分 类 号：R657[医药卫生—外科学]